468 A Viral Cause for CFS? [23 Apr 2018]

Last week I described chronic fatigue syndrome (CFS) and wrote that officially there is no known cause or cure. But is that true?

In their 2014 book Plague – One Scientist’s Intrepid Search for the Truth about Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism, and Other Diseases, Kent Heckenlively and Judy Mikovits tell the story of the discovery and cover-up of a possible cause (and cure) for chronic fatigue syndrome.

In 2006 Judy Mikovits, a virus research scientist with 30 years’ experience in studying HIV/AIDS, accepted a position in Nevada to study chronic fatigue syndrome. She immediately noticed several similarities between CFS and AIDS and began to suspect a viral cause. In both diseases an impaired immune system allows a wide variety of “opportunistic” infections; both have a high incidence of normally rare cancers; and both show abnormal brain scans and have similar biomarkers such as high cytokine production. Mikovits discovered a retrovirus infection in 67% of CFS sufferers and in 4% of healthy controls. She published her findings in 2009 in the prestigious journal Science.

This particular virus, called XMRV, is a mouse retrovirus, meaning that it originated in mice but had mutated and could now infect humans. XMRV had been associated with prostate cancer since 2006 (but has since been dismissed as a causative factor). The first CFS outbreak in the USA occurred in 1934-5 among the doctors and staff of the Los Angeles County Hospital after receiving a polio vaccine grown on mouse tissue. In the late 1970’s and early ’80’s pockets of CFS began showing up in cities across the country and then around the world. Today an estimated 20 million people world-wide suffer from the condition.

Patients and their families were hopeful that this discovery would lead to a cure or at least a more effective treatment. Alas this was not to be. For various reasons (to be covered next week) the medical research community turned on Mikovits, discredited her and her research, and reverted to the “no known cause” for CFS. The situation has not changed since, leaving at least one more generation of CFS patients to suffer needlessly.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

467 Chronic Fatigue Syndrome [16 Apr 2018]

Chronic fatigue syndrome (CFS), or myalgic encephalomyelitis (ME), is a complex disorder involving extreme fatigue. There is no definitive test for CFS – it is diagnosed by eliminating all other possible causes.

CFS can be very debilitating. One researcher compared it to end stage AIDS or advanced cancer, except that the victims can survive for years or even decades. Because they don’t die as quickly as in AIDS or cancer (and they have no energy to promote their cause), CFS research has not received the same attention. The majority of victims are female which may contribute to the dismissal of CFS by many government health organizations as psychological (“all in your head”).

The main symptoms and signs of CFS include:
• Extreme fatigue which does not improve with rest
• Even mild exercise worsens fatigue for more than 24 hours
• Brain fog – loss of memory and/or concentration
• Poor sleep quality
• Muscle and joint pain; headaches

Some characteristics of CFS that suggest an infectious not psychological cause:
• It appeared suddenly in the late 1970s, previously unrecorded
• Appears in clusters at different locations and times
• Sore throat and enlarged lymph nodes
• Opportunistic infections indicating an impaired immune system
• Much higher than normal incidence of certain rare cancers
• Abnormal brain scans resembling AIDS related dementia

CFS is much more widespread than one would expect given its low priority for research. Hillary Johnson writes “ME is now the most common chronic disease most people have never heard of until they acquire it.” CFS affects an estimated 20 million world-wide with more than 2 million in the USA (more than breast and lung cancer, AIDS, and MS combined).

The cause of CFS is officially “unknown”; a combination of factors is suspected possibly including genetic, viral/microbial, social and psychological. There is no known cure; treatment focuses on symptom relief.

Next week: XMRV – the cause of CFS?

Sources:
Mayo Clinic website
Health Canada website
book Plague – One Scientist’s Intrepid Search for the Truth about Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism, and Other Diseases. Kent Heckenlively and Judy Mikovits, 2014

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

458 Vitamin D, Colds and Flu [12 Feb 2018]

This has been an unusually bad year for influenza and severe colds, collectively called upper respiratory infections or URIs. Many observational studies have found that low levels of vitamin D are associated with increased risk for URIs. But the few random controlled studies testing to see if supplementing with D could lower the risk had conflicting results.

A meta-analysis published in February 2017 in the British Medical Journal combined the data from 25 randomized controlled trials to look at the effect of vitamin D supplementation on incidence of acute respiratory tract infection. It concluded that vitamin D supplementation was safe and offered some protection against acute respiratory tract infections, but only with frequent dosing (daily or weekly – not monthly or longer).

A study in Toronto published in JAMA in 2017 compared 2000 IU and 400 IU vitamin D (daily as oral drops) in 700 children over one respiratory season. Infections averaged slightly more than 1 per child with no significant difference between the two groups. Incidence of influenza infections was reduced 50% in the high dose group but there were too few (10% of infections) to be conclusive.

Last month a recent study of infants from China reported that high dose vitamin D reduced the risk of URIs and also improved symptoms. A random controlled clinical trial published in January 2018 in Pediatr Infect Dis J studied 400 healthy infants between 3 and 12 months of age. Half were given 400 IU and half 1200 IU vitamin D daily as oral drops. The infants were monitored for symptoms of fever, cough and wheezing for four months.

Over the four months 121 cases of influenza A infection occurred – 78 in the low dose group and 43 in the high dose group. As well as having fewer occurrences, the duration of the symptoms (fever, coughing and wheezing) were all significantly shorter in the high dose group. The authors concluded “High-dose vitamin D (1200 IU) is suitable for the prevention of seasonal influenza as evidenced by rapid relief from symptoms, rapid decrease in viral loads, and disease recovery. In addition, high-dose vitamin D is probably safe for infants.”

The Vitamin D Council recommends vitamin D supplementation of 5,000-10,000 IU per day for adults and 1,000 – 2,000 for infants. Vitamin D supplementation is especially important during the winter season when URIs are most common and of course when we cannot obtain vitamin D from the sun.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

449 Medicinal Mushrooms [4 Dec 2017]

Medicinal mushrooms are commonly used in Japan (hence the Japanese names for many of them) but are underutilized in North America, mostly I think due to lack of awareness. Most of the research, including many human studies, have been done in China and Japan. I didn’t know much about them until I participated in a webinar on the topic by Dr. Philip Rouchotas.

The active ingredients in the mushrooms are various polysaccharides which are protected in the mushrooms by a chitin cell wall. Hot water or steam extraction works best to release the polysaccharides.

Coriolus, Reishi, Maitake, Shiitake and Chaga all have similar medicinal properties. Their most important role is assisting with advanced cancer treatment, taken along with chemotherapy and radiation. These mushrooms have been used in Japan for this purpose for over 30 years. Studies have shown that they:

• Stimulate activity of NK (Natural Killer) white blood cells to attack cancer cells
• Protect Neutrophils from destruction by chemo, allowing treatment to continue (if neutrophil count gets too low chemo treatment has to be stopped)
• Reduce side effects of chemo and radiation therapy including fatigue, loss of appetite, nausea, and insomnia
• Help maintain body weight during cancer treatment
• Increase length of remission and survival rates from cancer treatment

These five mushrooms also have anti-viral properties and have been shown in human trials to be effective with HIV, HPV and other viral, fungal and bacterial infections. They also help with conditions of severe fatigue like Fibromyalgia and Chronic Fatigue Syndrome.

Cordyceps is another well studied mushroom, highly valued by the Chinese. An important use is in treating adrenal fatigue by balancing cortisol production. It improves symptoms of respiratory conditions including COPD. Cordyceps improves cardio-pulmonary function in elderly people, increasing their stamina.

Lion’s Mane is known as the “brain mushroom” because it stimulates nerve growth. It’s main use is with neurodegenerative diseases like Alzheimer’s, Parkinson’s and MS. Animal studies show that it increases growth of myelin making it a promising treatment for MS. Dr. Rouchotas considers it to be the most important supplement in treatment of brain injury such as concussion, along with fish oil, CoQ10 and Acetyl-L-Carnitine.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

403 Humic & Fulvic Acids [16 Jan 2017]

I have a rather unique supplement on my shelves that I wanted to learn more about so chose it for my topic this week. Humic and fulvic acids are organic compounds found in soil, peat, and water sediments. A particularly rich deposit in New Mexico dating from the Cretaceous Period (100mya) is mined to create a supplement for human use.

The main ingredients are humic and fulvic acids. The supplement also contains traces of amino acids, vitamins, minerals, plant enzymes and other organic compounds (organic in the chemical sense meaning that it contains carbon).

Humic and fulvic acids are known to benefit human health in many ways:
• Source of trace minerals in a readily available organic form
• Stimulates mitochondrial production of ATP
• Protects mitochondrial membranes from oxidative damage
• Reduces loss of ATP and CoQ10 levels during heavy exercise
• Acts as prebiotic feeding good bacteria in the gut
• Reduces pain and inflammation
• Improves immunity by increasing T-lymphocytes and neutrophils
• Inhibits viral infections including rhinoviruses, influenza and Herpes simplex
• Increases elimination of toxic heavy metals while improving absorption of nutritional metals like iron and zinc
• Blocks stress hormones
• Increases oxygenation of the blood

Here are how these benefits are experienced by users:
• Relief from joint pain and stiffness
• Reduced soreness and faster recovery from work or sports activity
• Increased energy & stamina
• Improved immunity from colds and flu
• Improved mood, reduced anxiety, increased alertness
• Most people noticed the benefits in 1 or 2 weeks

In over 10 years of research, humic and fulvic acid supplements have been found to be completely safe and do not interfere with any medications.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner. Find this article on my website for links to sources and further reading.

319 Increasing Glutathione – Who Can Benefit? [18 May 2015]

Last week (#318) I showed you how to raise your glutathione levels. Which brings up the question of who would benefit from increasing glutathione.

In medicine we think of one drug for one disease, and are taught to be skeptical of “panaceas” that promise everything. But in natural healing many different nutrients must work together to improve one condition; and a single nutrient can improve many different conditions. Glutathione is a perfect example of the latter because its powerful antioxidant properties make it essential for health in every cell of the body.

You could benefit from increasing glutathione levels if you:
• want to look and feel younger – as we age our bodies produce less glutathione
• are an athlete – improves strength, endurance and reduces recovery time
• are a smoker, welder, mechanic, chemical farmer, consume alcohol, or are otherwise exposed to chemical toxins – protects your organs from damage
• use a cell phone or WIFI, are exposed to microwaves or ultraviolet radiation – protects cells from radiation damage
• have a chronic disease like asthma, Alzheimer’s, Lupus, Parkinson’s, arthritis, macular degeneration – all associated with low glutathione
• are fighting a viral infection such as a cold, hepatitis, herpes, bronchitis, pneumonia, even AIDS – strengthens the immune system to fight infections
• have impaired or diseased organs including heart, liver, kidneys, prostate, stomach, intestines, colon – all benefit from increased glutathione
• have atherosclerosis (risk for heart attack & stroke) – prevents lipid peroxidation and plaque formation
• are healing from trauma – promotes growth of healthy new tissue
• want to sleep better – promotes better more restful sleep
• are sick and tired of feeling sick and tired – supports mitochondria to produce more energy
• are healthy and want to stay that way – helps prevent all above conditions

Sources:
Immunotec website
Nutraxis website

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

173 Gut Flora and our Immune System [9 July 2012]

Last week we looked at the benefits of gut flora. In this column I’ll concentrate on the effects of gut flora on our immune system. Dr. Natasha Campbell-McBride, in “Gut and Psychology Syndrome – Natural Treatment for Autism, ADHD, Dyspraxia, Depression and Schizophrenia”, explains how the immune systems of people with GAPS Syndrome (discussed last column) are out of balance, often attacking their own bodies including the brain and nervous system.

Beneficial bacteria coat the epithelial surface of the small intestine and stimulate production of lymphocytes which in turn produce immunoglobulins, especially IgA, and other immune system regulators such as cytokines and interferons. These are our body’s first line of defense against pathological microorganisms. Beneficial bacteria also enable neutrophils and macrophages to function better. Their job is to destroy and gobble up viruses, bacteria and toxins.

The health of our gut flora affects the immune system of the entire body, not just that in the digestive tract. When the first line of defense in the lining of the gut fails, pathogens and toxins enter the bloodstream and our second line of defense is activated. This includes several different interleukins and IgE, the antibody involved in allergic reactions. These are not as effective at fighting pathogens, often allowing chronic viral infections to persist. If these antibodies become overactive they can lead to allergic and auto-immune conditions including asthma, eczema, chronic fatigue syndrome and neurological conditions like ADHD and autism.

Two additional effects of gut flora on the immune system are malnutrition and auto-intoxication. The nutrient deficiencies caused by a lack of beneficial bacteria (discussed last week) affect the immune system along with every other system of the body. And the unchecked growth of pathogens produces toxins like ethanol and acetaldehyde which depresses the immune system and attacks the nervous system.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

170 Lysine – the “Cold Sore Cure” [18 June 2012]

Lysine is one of the eight essential amino acids, meaning that we must obtain all our daily needs in our diet. That is usually not a problem as lysine is found in meat, fish, poultry, eggs, pulses (lentils, beans and peas) and dairy. A vegan diet depending on grains for protein would be deficient in lysine, so it is commonly added to animal feed.

Lysine is an essential building block for all protein in the body, including hormones, enzymes and antibodies. It is important for increasing muscle and in the healing of wounds or surgery. Lysine plays a role in calcium absorption and is essential in the production of collagen, a protein found in skin, tendons and cartilage. Lysine also helps regulate serotonin, one of the anti-anxiety neurotransmitters I discussed in column #167.

Lysine is sometimes taken as a supplement to help fight infections of herpes simplex virus which causes cold sores. For this purpose, lysine is often taken in a formula along with zinc, vitamin C, bioflavonoids, and immune-supporting herbs like garlic, echinacea and goldenseal. Studies have found that a diet high in lysine and low in arginine reduces the frequency and severity of herpes outbreaks.

Lysine appears to inhibit herpes infections by suppressing arginine, the amino acid I wrote about last week, which is essential for the virus to replicate. Arginine and lysine compete with each other for absorption, so increasing lysine will create a relative deficiency of arginine. So if you are taking lysine for this purpose, you should avoid supplementing with arginine and temporarily reduce consumption of foods high in arginine (see list in last week’s column). Because arginine is also important to our health, long-term supplementation of lysine is not recommended.

Speaking of arginine, two functions that I missed mentioning last week are:
• arginine enhances the immune system by stimulating the thymus gland to increase production of B and T cells
• arginine stimulates the pituitary gland to produce human growth hormone (HGH)

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.