477 Depression Biotypes [25 June 2018]

In his book Nutrient Power – Heal Your Biochemistry and Heal Your Brain, William J. Walsh describes the five major depression biotypes that he discovered over 20 years collecting data on nearly 3,000 depressive patients. Like the schizophrenia biotypes discussed last week, each depression biotype has its own unique biochemistry, neurotransmitter imbalances, symptoms and characteristics. Walsh also outlines the nutrient therapy protocols he developed to correct the imbalances.

Undermethylated depression (38%) is characterized by reduced serotonin and dopamine activity. Patients tend to be high achievers and perfectionists, with a high tendency to suicide. SSRI meds offer some improvement. Beneficial nutrients include SAMe and methionine. Avoid folate, choline, and certain other nutrients.

Folate deficiency depression (20%) is characterized with elevated serotonin and dopamine. Patients tend to also have anxiety and ADD, and frequently have food and chemical sensitivities. They are intolerant to SSRI antidepressants (sometimes suicidally), antihistamines, SAMe and methionine. They improve with folic acid and certain other nutrients, and need to avoid tryptophan, 5HTP and some others.

Copper overload depression (hypercupremia) (17%) is characterized by elevated norepinephrine and reduced dopamine activity. These are usually women, often with a history of post-partum depression. They may also have anxiety, sleep disorder, childhood hyperactivity, tinnitus and estrogen intolerance (birth control pills, chocolate worsens depression). Nutrient therapy includes zinc, manganese, and several antioxidant nutrients.

Pyrrole disorder depression (15%) is characterized by reduced serotonin, dopamine and GABA. Depression is often severe with anxiety, low stress tolerance and extreme mood swings. Improvements are rapid with nutrient therapy including B6 or P5P, zinc, selenium, and manganese.

Toxic metal overload depression (5%) weakens the blood-brain barrier, disables brain antioxidants, and damages the myelin sheath. Nutrient treatment may include EDTA chelation and supplementation of vitamins and minerals which will depend on the metals involved, usually lead, mercury, cadmium and arsenic.

The takeaway lesson here is that there are several conditions usually lumped together as “depression”, each with a different cause. It is critical to know the biotype because the commonly prescribed serotonin enhancing drugs work well on a few types, don’t work on a few others, and can be fatal for another. A good case history and a few blood tests can determine which group a depressive patient is in and therefore which therapy protocol is most likely to benefit.

The second lesson is that there are nutrient therapies that effectively correct the imbalances without the usual side effects of the psychiatric drugs.

Again, like with the schizophrenias, diagnosis and nutrient therapy should be undertaken only under the supervision of an experienced professional.

Next week: autism.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

441 EPA not DHA [9 Oct 2017]

The two most important Omega-3 essential fatty acids for our health are Ecosapentanaenoic Acid (EPA) and Docosahexanoic Acid (DHA). Both are found in fish oil supplements. As I alluded to in a column last month [#438 Nutrients for Mental Health] EPA is the critical one for mental health.

EPA has been found to be the more effective of the two for depression. A meta-analysis published in 2011 in J Clin Psychiatry found that supplements with an EPA:DHA ratio of 3:2 or higher with doses of 200 to 2,000 mg per day were effective in treating depression, and the higher the ratio, the more effective it was. A 2013 study in Eur Neuropsychopharmacol found that EPA but not DHA improved depression symptoms in adults already taking antidepressant drugs. Another study found that fish oil worked better than Prozac for depression, but both together worked better than either alone.

Attention Deficit Hyperactive Disorder (ADHD) is another condition where Omega-3’s show promise. An Australian study published in J Dev Behav Pediatr in 2007 found significant improvement in attention, hyperactivity and impulsivity. A review and meta-analysis published in 2011 in J Am Acad Child Adolesc Psychiatry found a modest but significant reduction in ADHD symptoms with Omega-3 supplementation and concluded that because of its “benign side-effect profile” it “may be reasonable to use omega-3…to augment …pharmacologic interventions or for families who decline other psychopharmacologic options”. Another study [J Atten Disord 2009] found that after 6 months of Omega-3 supplementation, 47% of the children in the study had a reduction of ADHD symptoms to near normal. Of 12 studies on high EPA supplementation for ADD, 11 showed positive results. Of five studies using DHA, only one showed a positive result, and that showed improvement in only 7 of 16 possible markers.

Dr. Philip Rouchotas, ND, of Bolton Naturopathic Clinic in Ontario finds that 1,000 mg of omega-3 daily of a 2:1 ratio fish oil with works best for most conditions but mental health and mood disorders require a higher EPA:DHA ratio with 1,000 mg of EPA. He prefers capsules to liquid as the oil is better protected from oxidation. Rouchotas also finds that the ethyl ester form works as well as the triglyceride form, is less expensive, and allows much higher potency per capsule.

Most of the fish oil supplements in my store are slightly higher in EPA than DHA or at best 2:1. A new line I just brought in has a general purpose 2:1 ratio formula and a higher 10:1 ratio formula with 1,000 mg EPA for healthy mood balance.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

438 Nutrients for Mental Health

One in five Canadian adults are on a prescription drug for a mental health problem. The most common – depression, anxiety and insomnia – frequently occur together. Nutritional supplements can greatly benefit people with these mental health issues. The protocol varies slightly depending on whether they are on a prescription or not.

For those already on a mental health prescription, the following have proven beneficial and completely safe:
• Fish oil with high EPA (e.g. 1000 EPA, 200 DHA)
• Vitamin D 2,000 IU (more if blood levels low)
• Good multi or B complex with bioactive form of B vitamins
• Melatonin (adjust to individual need)

For those not on prescription meds, use the same fish oil and vitamin D with these additional natural products:
• Melatonin or an herbal/nutrient sleep aid
• Anti-stress and mood elevating formulas that may include: bioactive B vitamins, choline, & inositol; amino acids L-theanine, L-tryptophan, PABA, 5-HTP, GABA, & SAMe; and botanicals like ashwagandha, valerian, passionflower, rhodiola & holy basil.

Be cautious with herbs if you are taking a prescription drug as they can affect the rate of drug processing by the liver and change the drug’s effective potency.

The ratio of EPA to DHA in fish oil is critical. For almost all situations, oils with higher EPA (at least 2:1) work better, especially for mood. Oils with higher DHA have been shown to worsen mood and aggression. This holds for children with ADD – the high EPA formulas help; the high DHA ones do not, and could worsen symptoms.

Omega 3 fish oil is often under-supplemented. At low doses (250-900 mg total EPA+DHA) it is has been shown to reduce the risk of sudden coronary death. But at higher doses (2,000-4,000 mg) it also reduces risk of non-fatal coronary events (angina); improves blood lipid values (triglycerides & cholesterol); and reduces pain and inflammation (arthritis, etc.). 1000-3000 mg of 2:1 EPA:DHA is ideal for neurodegenerative conditions like dementia, Alzheimer’s, Parkinson’s & MS.

Source: "Mental Health" webinar by Philip Rouchotas MSc, ND, September 11, 2017, sponsored by New Roots Herbal

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

415 Diet & Depression [10 April 2017]

Depression is a significant health and economic problem in Canada, costing an estimated $32 billion to the economy each year and causing untold suffering for the 3.5 million Canadians who will experience it at least once during their lifetime. Traditional treatment currently includes psychotherapy and psychiatric medication, with limited success. Recent research is starting to find that diet and lifestyle factors are also important, something I have been saying for years (#74 August 2010; #297 Dec 2014).

In my article #300 Medicate or Nutrate (January 2015) I quote Dr. Julia Rucklidge who proposed that lifestyle factors (healthy eating, exercise & supplements) should be the first priority in treating mental illness, followed by psychological and medication treatments only when necessary.

A random controlled trial by Deakin University’s Food and Mood Centre (in Geelong, Australia) was the first to test the effect of improving the diet on clinical depression. Participants were randomly assigned to either receive social support or assistance to improve the quality of their diets. Dietary improvements included increasing vegetables, fruits, wholegrains, legumes, fish, lean meats, olive oil and nuts, while reducing refined cereals, fried food, processed meats and sugary drinks and desserts. The dietary group showed a much greater reduction in their depressive symptoms over three months than the social support group. Furthermore, those who followed the dietary program more closely improved the most.

The lead author Professor Felice Jacka, president of the International Society for Nutritional Psychiatry Research, said this study offers an important new strategy for the treatment of depression and suggests adding clinical dieticians to mental health care teams. Professor Jacka added “It also supports the previous extensive research from human population studies and animal research suggesting that diet is a key determinant of mental and brain health”.

If significant improvements in depression symptoms can be seen with just three months of basic dietary improvements, just think how much more could be accomplished with the addition of adequate supplementation of vitamins, minerals, essential fatty acids, and amino acids, along with optimum exercise and sunlight!

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

394 Many Benefits of Sunlight [7 Nov 2016]

This week we will explore the many health benefits of sunlight. A rather ironic topic since we are entering the season of lowest sunlight here in Saskatchewan. Sunlight provides us with a broad spectrum of radiation in the 300 – 2,000 nm wavelength range, of which only 400 – 780 nm is visible. And most of that range is proving to be beneficial, if not essential, to our health.

The most well-known and studied benefit of sunlight is vitamin D synthesis in the skin from ultraviolet B (UVB) wavelengths. I have written many times [#179, 328] on how to optimize vitamin D synthesis while minimizing risk of skin cancer.

Another benefit is in preventing and treating depression. Seasonal Affective Disorder [#041] caused by the shorter days of winter can be effectively treated with special sun lamps. Other types of depression also respond to light therapy [#347]. Lamps designed for this light therapy usually lack the UVB necessary for vitamin D synthesis – the only vitamin D lamp I am aware of is the Sperti Sun Lamp at $650.

Sunlight regulates our circadian rhythms, helping us to stay alert during the day and sleep at night. Blue wavelength light in the evening is especially bad for keeping us awake. Wearing orange tinted sunglasses in the evening, even in the house, should help you sleep better.

Full spectrum fluorescent lighting has been found to reduce stress hormones, improve behavior problems, and calm hyperactivity in school children. Workplaces installing full spectrum lighting report improved employee morale, greater productivity, reduced errors and decreased absenteeism [#012].

Recent research has shed light (pardon the pun) on the benefits of near infrared (IRA) light on our health. This is the light that is just beyond red – we can’t see it and do not feel it as heat (the far infrared IRB and IRC do produce heat). Infrared A is not produced by non-thermal light sources (fluorescents and LCDs) and is filtered out by window glass, so the only sources are incandescent lights, fire and, of course the sun. IRA penetrates through clothing and skin, deep into the tissue where it activates an enzyme, cytochrome C oxidase, in the mitochondria which increases ATP energy production. And who couldn’t use more energy? Unfortunately most infrared saunas emit the far IR and lack the beneficial IRA.

There is no substitute for sunlight. All artificial light sources are lacking in some vital spectra that we need for optimal health, referred to as “biological darkness”. Those of you who can go south for the winter can continue to obtain these benefits; the rest of us are left behind in the biological dark.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

347 Light Therapy & Depression [30 Nov 2015]

I wrote about Seasonal Affective Disorder (SAD) back in December 2009 and discussed exposure to full spectrum light as one of the effective treatments. A recent Canadian study suggests that this light therapy might also be effective for non-seasonal major depressive disorder (MDD). Previous studies on light therapy for MDD were poorly designed and inconclusive.

A study published this month in JAMA Psychiatry randomly divided 122 people from clinics in Vancouver and Toronto with moderate to severe non-seasonal depressive disorder into four groups: light therapy and fluoxetine hydrochloride (an antidepressant pill); light therapy and placebo pill; fluoxetine and placebo device (inactive ion generator); and both placebos. The light therapy consisted of a 30 minute exposure to a strong (10,000 lux) fluorescent light box every morning.

After 8 weeks improvement was observed in about 75% of the patients receiving the light therapy with the antidepressant; about 50% of those receiving the light therapy alone; about 29% for the antidepressant alone; and 33% for the placebos. The study concluded that “Light treatment, whether in monotherapy or in combination with fluoxetine, is efficacious and well tolerated in the treatment of nonseasonal MDD.” Surprisingly the antidepressant alone appears less effective than placebo, but this study was too small to draw any conclusions on this observation. An earlier study showed that fluoxetine and light had similar benefits in patients with SAD.

The researchers speculated that light therapy may resynchronize circadian rhythms that have become disturbed in MDD or rebalance neurotransmitter function. Sunlight triggers the pineal gland to produce more serotonin and less melatonin. Low serotonin is associated with depression and carbohydrate cravings; high melatonin with sleepiness and loss of concentration.

Michael Terman, PhD, professor of psychiatry, Columbia University, commented on the study:

“…the dramatic …result …[means that] 10,000 lux light therapy upon awakening or, by implication, a walk outdoors if the sun is up – now can be recommended to patients with recurrent depression, many of whom will respond without recourse to drugs.”

So if you are suffering from depression, talk to your doctor about adding light therapy to your treatment. Caution – people with certain eye conditions or with bipolar disorder should not use the light therapy.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

332 Children & Nature [17 August 2015]

We’re getting real summer weather this week, with highs around 30C – perfect for spending time at the lake. Many Canadians enjoy spending part of their summer holidays at the lake, either in the family cabin or camping. We find it relaxing to get away from the “rat race” and “back to nature”, and return to work or school feeling refreshed and invigorated.

What scientific evidence backs our belief that nature improves our mental and emotional health? Here are what some studies have found about the benefits of nature for both children and adults:

• The physical activity of 11-13 year old Canadian children increased with the amount of tree-filled space in their neighborhoods.
• Children in Maryland and Colorado who played in green schoolyards reported less stress and showed increased feeling of competence than those whose schools had no grass or trees.
• A study in Illinois found a 20 minute walk in the park boosted the focus and attention of 17 children diagnosed with ADHD.
• Greater amount of greenness at home and especially at school increased cognitive improvements in schoolchildren in Barcelona, Spain.
• Children in nature-based playgrounds engage in more creative play and use their imaginations more to create their own games.
• Camping together improved family relationships for 86% of respondents in a survey of 60 American families.
• Childhood experience with wild nature is positively associated with their appreciation of nature as adults.
• Japanese “forest bathing” (basking in a natural treed environment) lowers blood pressure and reduces stress hormones.
• A 2009 study from the Netherlands found that green space in people’s living environment significantly reduced anxiety disorder and depression.
• A 2012 study found walking in nature improved mood and short-term memory in 20 adults with major depression.

With the increasing time children (and adults) spend on their phones and playing video games (one estimate was that children play outside less than half the time their parents did), it would seem to be even more important for parents and teachers to provide opportunities for them to spend time in nature.

Sources for further reading:
Centre for Confidence and Well-Being
The Center for Parenting Education: Nature and children - a natural fit
MindBodyGreen 5 Really Good Reasons Why Kids Ned Time in Nature
MBG 10 Great Reasons to Get Outside More Often
MBG 7 Science Backed Reasons to get Your Kids Outside
MBG Why You Need to Try Japanese Forest Bathing
J. Mercola Green Spaces Make Kids Smarter

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

320 Our Gut Microbiome & Our Brain [25 May 2015]

Last fall (#287 & #288) I discussed how our gut microbiome (the bacteria in our intestines) affect our health in many ways, and how it in turn is affected by our diet and lifestyle choices.

In his new 2015 book Brain Maker, the Power of Gut Microbes to Heal and Protect your Brain – For Life, neurologist Dr. David Perlmutter expands on this idea with new research into the relationship between our microbiome and our brain health. The book discusses the gut microbiome’s effect on: inflammation; mood disorders like depression; diabetes and obesity; and neurological disorders like autism, ADHD, Parkinson’s, MS and Alzheimer’s.

These bacteria living in our digestive tract make up 99% of the DNA in our bodies, and affect our health in several ways:
• manufacture neurochemicals like dopamine and serotonin, and vitamins like B12;
• maintain the integrity of the gut lining preventing “leaky gut syndrome”; and
• control switches that can turn our own genes on or off.

Leaky gut and inflammation seems to be the keys to the common brain disorders mentioned above. Gut permeability can be measured by measuring levels of lipopolysaccharide (LPS) antibodies – higher blood levels indicate a leaky gut. Strong correlations have been found between LPS levels and many of these chronic disorders, including diabetes. Correlation of course doesn’t necessarily mean causation, but Dr. Perlmutter made some interesting observations after correcting gut flora with fecal transplants (see #243) in a few case studies: Carlos, a 43 year old man with MS who could barely walk with two canes, could now walk unaided; and Jason, a 10 year old boy with severe autism showed remarkable improvements.

While our own DNA has changed little in thousands of years, we can change the 99% of the DNA in our bodies that are found in the gut microbiome in a matter of days – and in so doing significantly reduce our risk for these neurological conditions – simply by changing our diets. More about this in a future article.

Sources: Dr. Perlmutter interview (1 hour)

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

300 Medicate or Nutrate? [5 Jan 2015)

For my 300th article (and the first for 2015) I’m going to follow up on #297 from Dec 8 on mental health.

Dr. Julia Rucklidge in her TEDx talk suggested we reconsider our current treatment approach to mental illness – psychiatric medication first, followed by psychological therapies, with nutrition as an afterthought (if considered at all). Instead she proposes the first priority be lifestyle factors (healthy eating, exercise, supplements) and when necessary psychological treatment, and save medications for when these approaches prove insufficient.

Anthony Stephan, founder of TrueHope, argues that it’s better to nutrate our brains than to medicate them. He prefers to call mental illness “nutritional deficiency mood disorders” and believes that given sufficient nutrients the body can heal itself.

Putting nutrition first makes sense to me. The brain makes up 2% of body mass but consumes 20% of our energy and uses a disproportionately high amount of our daily intake of nutrients. How can we expect it to function properly if our diets are depleted in essential nutrients? Kaplan & Rucklidge in their December 9, 2014 madinamerica.com article “Nutrient Boosting of Medications” put it more technically:

...psychiatric symptoms may be the result of inborn metabolic dysfunction associated with slowed metabolic activity caused by insufficient vitamin and mineral cofactors.

Note that nutrient dosages much higher than the RDA are usually required to compensate for these metabolic dysfunctions.

Research on micro-nutrition and mental illness (25 published studies to date) shows positive often dramatic improvements with a broad spectrum high dose nutrient supplementation on a variety of conditions: depression, bi-polar disorder, autism, ADHD, OCD, PTSD, stress, anxiety, mood & behavior, and addiction. Over the last 16 years TrueHope and its micronutrient supplement has helped tens of thousands of people with mental illness return to a normal life and either reduce or eliminate their psychiatric medications. Shouldn’t this be our primary treatment for mental illness: nutrate rather than medicate?

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

297 Mental Health Revolution [8 Dec 2014]

The discovery of the first anti-depressant in the 1950s ushered in a revolution in mental health. This and the families of anti-depressant, anti-anxiety and anti-psychotic drugs that followed not only provided results not possible before but did much to remove the stigma of mental illness. They showed that mental illness is a chemical imbalance, not a character flaw, and not the fault of the person experiencing it.

Unfortunately, recent research is finding that while these drugs have good short term results, the long term can be a different story. Dr. Julia Rucklidge, a clinical psychologist in New Zealand, expanded on this topic in a recent TEDx Talk. She reported huge rates of increases over the past few years in ADHD, autism, bipolar disorder and other psychiatric illnesses in New Zealand and internationally, and then discussed the long term shortcomings of conventional treatments.

Rucklidge has spent the last ten years researching the effects of micro-nutrition on mental health. She and other researchers around the world, have found that the broad spectrum high dose supplement she works with consistently provides superior, often dramatic, results in the short term, without the long term side effects of conventional treatments, for many different conditions including: stress, anxiety, addictions, depression, ADHD, OCD, autism, and Bipolar Disorder. Links to these studies can be found on the TrueHope website. She explains that eating well is essential for mental health but for some people it is not sufficient to turn around a serious mental condition. She also cautioned that the number of nutrients (36) and the dosage used by the researchers are far higher than you would find in a regular multivitamin.

I first wrote about this program in January 2010 "A Discovery of Truehope". Listen to an interview with Truehope founder Anthony Stephan talking about the program and how it came to be.

Rucklidge sums it up this way:

“Poor nutrition is a significant and modifiable risk factor for the development of mental illness… Optimizing nutrition is a safe and viable way to avoid, treat or lessen mental illness.”

I think it’s time for the next revolution in mental health.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

255 Luobuma – the Anti-Stress Tea [18 February 2014]

Two plants growing in a remote desert in central Asia have shown some remarkable properties for dealing with stress and other health problems. Apocynum venetum and its close relative Apocynum hendersonii grow in the Taklamakan desert in the Tarim Basin situated in western China. The leaves and flowers are picked during the hot summer months. Tea, or an aqueous extract of this herb, is known as Luobuma and is popular in China as a healthful beverage.

Luobuma has been used in Asia as a medicinal herb for over a thousand years. Modern research has found a high content of quercitin, an important antioxidant phytochemical known to reduce blood pressure, and many other phytochemical compounds some of which are similar to those in St. John’s Wort, and others which are unique to Luobuma.

Luobuma has been found to:
• Relieve stress and anxiety
• Relieve depression
• Improve sleep
• Reduce high blood pressure
• Relieve headache, dizziness and vertigo
• Reduce cholesterol
• Strengthen cardiac muscle
• Relax cardiac arrhythmia
• Protect the liver from chemical toxicity

Luobuma has a good safety record with no known adverse effects. It is available as a tea or in capsules. Specific formulas combining Luobuma with various other herbs are available for blood pressure, cholesterol, headaches, and dizziness/vertigo. I have tried the tea and it has a mild flavor, similar to chamomile or green tea.

See the website www.luobuma.ca for more information.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

248 Phosphatidyl Serine [23 Dec 2013]

Last week I discussed the uses of phosphatidyl choline in cell membrane function; this week we’ll look at its molecular cousin, phosphatidyl serine (or PS for short) and its role in the brain. Like its choline counterpart, PS is a phospholipid found in the cell membrane, but in much smaller amounts. PS is particularly abundant in nerve cell membranes of the brain where it plays a role in inter-cell communication. Our bodies can create PS from phosphatidyl choline but can also obtain some directly from our food. PS occurs in meat, fish, and organ meats particularly brain, but by far the most abundant food source of PS is soy lecithin. As with phosphatidyl choline, our production of PS decreases as we age which may contribute to a decline in brain function.

Double-blind studies in the USA and Europe have shown that PS supplementation can reverse this trend. Specifically, taking PS has been found to improve short and long-term memory and concentration in people with mild to moderate cognitive dysfunction (it doesn’t help much with more severe dementia). PS has also been shown to improve mood, reduce depression and increase social interaction in older people. Phosphatidyl serine supplements, in dosages of 200mg per day, have been used successfully for children with ADHD. PS has also been used, in higher doses, by athletes to reduce exercise-induced stress and soreness.

Phosphatidyl Serine supplements used to be extracted from bovine brain but since the BSE (mad cow) epidemic manufacturers have switched to making it from either soy or sunflower lecithin. Most of the early studies were done with bovine PS – more recent studies with soy based PS have shown less consistent results.

Because phosphatidyl serine is found in every cell of the body, it is a very safe nutrient with only a few rare, mild side effects. The goal of supplementation is to bring the levels of PS in the cell membranes back to what it was when we were younger. Therapeutic effects are dose dependent. For prevention 100mg per day is recommended; to treat age-related mental impairment 200-300 may be needed. PS is commonly sold in 60 and 100mg strengths.

Sources:
Wikipedia Phosphatidylserine
Web MD PS Overview Information
Web MD PS Uses, Side Effects, Interactions
Soy PS study in Japan
Natural Factors monograph

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

186 Amino Acids & Mood Disorders [9 October 2012]

Customers at my store often ask for certain supplements – usually single amino acids or other neurotransmitter precursors – to help with mood disorders. For example: tryptophan and melatonin for insomnia; theanine and 5-HTP for anxiety; or tyrosine and glutamic acid for depression. These can be effective and safer than pharmaceuticals but still don’t get at the root cause of the problem.

Dr. Jonathan Wright in his website Nutrition and Healing recommends testing for amino acid levels and supplementing with a customized supplement that includes all eight essential aminos. This is preferable to just taking one or two because balance is critical with aminos. Then he takes it a step further and looks for possible causes of amino deficiencies. It may be a diet lacking high quality protein, low stomach acid, insufficient pancreatic enzymes, gluten sensitivity or food allergies. Another possible root cause is dysbiosis – a lack of beneficial bacteria in your intestines (see my column #147 “The Brain-Gut Connection”).

If you think you might benefit from amino acid supplementation, ask your doctor for an amino acid level test. If that is not possible, a compromise would be to take an amino complex along with one or two of the aminos you think would help you. Dr Wright recommends B12 & folic acid supplementation along with the aminos. Betaine hydrochloride and digestive enzymes will help with protein digestion. A good probiotic program will restore beneficial gut flora. A fish oil supplement would be another good addition to your mood enhancement program. For more ideas see my columns #24 “Food & Mood”; #74 “Depression”; #75 “Omega 3s & Depression”; and #167 “Zesty or Tranquil”. These are available from my website (see below). It may take several months for your body to build up the neurotransmitter levels back to normal, so don’t give up too soon.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

180 Nitric Oxide – Say “NO” to Disease [27 August 2012]

Nitric oxide (NO) is a simple molecule – just one atom of nitrogen and one of oxygen – but it plays some very important roles in the body. The discovery of NO’s role in cell communication won a 1998 Nobel Prize. I touched on the functions of NO in my June 11 article (#169) on the amino acid arginine. Here is more information on nitric oxide:

• NO lowers blood pressure by relaxing the smooth muscles of the endothelium (lining of the blood vessels) thus dilating the arteries. It also prevents or reverses arterial plaque, keeping the artery walls flexible.
• NO increases blood flow when partially blocked arteries to the heart cause angina pain (which is how nitroglycerine pills work).
• NO increases blood flow when partially blocked arteries to the leg muscles cause muscle pain called intermittent claudication.
• The increased circulation dramatically reduces nerve and joint inflammation, providing relief for arthritis sufferers and improves healing of wounds and diabetic foot ulcers.
• NO lowers cholesterol – a clinical trial found that increasing NO lowered triglycerides by 27% in 30 days, from an average 232 down to 168 (mg/dL).
• Insulin requires NO to function properly; low levels of NO result in insulin resistance which, as I’ve written on extensively in past articles, can lead to obesity, high blood pressure, hyperlipidemia and Type 2 Diabetes.
• Low NO levels are associated with depression; treatment with antidepressants increases NO.
• NO is essential for both short-term and long-term memory.
• NO is also essential for penile erection; a deficiency of NO is a common cause of erectile dysfunction in older men.
• As we age, NO production in our bodies decreases; most people over 40 don’t produce enough. A simple saliva test can tell you where your level is.

Until recently taking arginine has been the best way to increase NO, but a much more effective supplement called Neo40 is now available in Canada. For more information on NO and Neo-40 see www.neo40.ca and a book called “The Nitric Oxide (NO) Solution” by Nathan S Bryan and Janet Zand, 2010.

With all these functions of nitric oxide, and most of us over 40 having insufficient levels, Neo40 has tremendous potential for improving our health in many different ways. I’m excited to learn what it will do for me. How about you?

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

175 The GAPS Diet [23 July 2012]

Dr. Natasha Campbell-McBride, in her book Gut and Psychology Syndrome, offers hope of a natural treatment for a wide variety of disorders including autism, asthma, allergies, ADD, ADHD, dyslexia, depression, bipolar, schizophrenia, and severe digestive disorders. If you think you or a family member might benefit from this program I recommend you get a copy of the book. You can see an outline of the program at www.gapsdiet.com, which I will further simplify here so you can get an idea of what all is involved.

There are three components to the program: diet, supplementation and detoxification. The GAPS diet is based on the Specific Carbohydrate Diet promoted by Elaine Gottschall in her book Breaking the Vicious Cycle – Intestinal Health Through Diet. Grains, dairy and processed foods are eliminated; certain meats, vegetables and fruit allowed. There is an Introduction Diet recommended to start with before going on the full GAPS diet.

Supplements include, of course, a therapeutic strength probiotic. Fermented foods like sauerkraut and kefir are also used to help re-establish healthy bacteria in the gut. For essential fatty acids use a good seed or nut oil and a high-EPA fish oil. Digestive enzymes and Betaine HCl are used to aid digestion. Vitamin A as cod liver oil is recommended. Specific nutrients that are determined to be deficient may be supplemented but other supplements are discouraged.

Eliminating toxin sources is the first and most important step towards detoxification by avoiding chemicals in food, household and cosmetic products. Juicing is recommended to help the body detoxify by providing concentrated nutrients in an easily absorbed form.

This may sound quite formidable but the book explains it well and makes it easier with tips and recipes. Certified practitioners who could assist you with the program are listed on the website – there are 3 in Alberta. Keep in mind that this program is temporary and becomes less strict as the digestive and immune systems improve, although some elements may have to be continued for life.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

147 The Brain – Gut Connection [9 January 2012]

A neurologist trained in Russia, now practicing in the UK, has developed a program to heal the digestive tract, which has greatly benefited her patients with neurological and psychiatric disorders ranging from autism to schizophrenia. Dr. Natasha Campbell-McBride believes that brain dysfuction is usually connected to problems in the digestive system. She calls her program “Gut and Psychology Syndrome” (or GAPS) and has written a book titled “Gut and Psychology Syndrome – Natural Treatment for Autism, ADHD, Dyspraxia, Depression and Schizophrenia”.

Dr. McBride became interested in nutrition when her son was diagnosed with autism. Her research resulted in her obtaining a master’s degree in human nutrition – and in the full recovery of her son who is now symptom free. In her book McBride explains how the digestive system affects many other areas of our health including the nervous system.

There are three parts to the GAPS program:
1. A special diet to support the regeneration of the enterocytes which line the digestive tract
2. Probiotics and fermented foods to establish healthy bacteria in the gut
3. Gentle detoxification

We produce important neurotransmitters in the gut, including serotonin. This may partially explain the connection between an unhealthy gut and neurological disorders. A healthy gut lining also prevents toxins, microbes and partially digested proteins from entering the bloodstream where they can trigger a wide range of health problems throughout the body including the brain. This situation, called “Leaky Gut Syndrome” would be a good topic for a future column.

You can learn more about Dr. McBride and the GAPS program at www.doctor-natasha.com and www.GAPS.me. On the latter website there is a list of practitioners trained to lead you through the program – the closest are three in Alberta.

This article is intended for educational purposes only; for medical advice consult your licensed health practitioner.

146 Many Benefits of Exercise [2 January 2012]

It’s the beginning of a new year and time to make our New Year’s resolutions. What single change will give you the biggest benefit for improving your health?

I found a video lecture that makes a good pitch for exercise. It’s called “23-1/2 Hours” by Dr Mike Evans, a physician and professor at U of Toronto. Watch it here (it’s fun and only 9 minutes).

Evans shows how exercise can help in so many different aspects of our health. Studies have shown exercise reduces:
• 47% pain & disability with arthritis of the knee
• 58% development of diabetes of those at high risk
• 30-47% symptoms of depression, depending on amount of exercise
• 41% risk of hip fractures in post menopausal women
• 23% risk of death in the large Harvard alumni study.

In a study of 50,000 people, Stephen Blair of U of South Carolina, found that low cardio-respiratory fitness was the single best predictor of death (hypertension was a close second). He also found that exercise “ameliorated much of the negative consequences of obesity” (which means being fat is not so bad if you keep fit).

An Australian study found that people who watch 6 hours of TV a day live, on average, 5 years less than those who watch none (Canadian adults average just over 4 hours). A Japanese study comparing commuting time (walking) and hypertension found that up to 10 minutes made no difference, 11-21 minutes reduced the incidence by 12%, and over 20 minutes reduced it by 29%.

So if exercise is the best medicine, what’s the dose? More is better, but the rate of return delines after 30 minutes per day (60 minutes for children). Evans ends with the challenge to limit our sitting and sleeping to 23+1/2 hours a day.

My paper route gives me an hour of walking 6 days a week, but when the alarm goes off at 6 am I can’t help but wonder if the benefits make up for losing 2 hours of sleep!

This article is intended for educational purposes only; for medical advice consult your licensed health practitioner.

104 Importance of Sleep [7 March 2011]

Last week we looked at sleep as important for the production of the hormone leptin which suppresses appetite and promotes burning rather than storage of fat. Weight gain is only one of many heath problems caused by inadequate sleep. Here are a few more:
• Fatigue, inability to concentrate, and irritability
• Higher risk of cardiovascular disease
• Increased risk of high blood pressure
• Weakened immune system – more susceptible to colds and flu
• More rapid tumor growth – sleep is critical if you are fighting cancer
• Digestive problems like stomach ulcers and constipation
• Depression and other mood disorders
• Increased cortisol production which can lead to memory loss and insulin resistance
• Lower production of melatonin which, besides regulating sleep, is an important antioxidant
• Reduced production of Growth Hormone (by the pituitary gland during sleep) which causes more rapid aging. You not only feel older – you are older!

The Canadian Sleep Society reports 1 out of 3 Canadian adults have some problem sleeping, and for 1 out of 10 it is serious enough to affect their health. Loss of sleep is cumulative and cannot be made up by sleeping in on the weekend; it’s important to get adequate sleep every night. For growing children and teens, sleep is even more important. Next week we’ll look at some natural ways to promote healthy sleep.

This article is intended for educational purposes only; for medical advice consult your licensed health practitioner.

075 Omega 3s & Depression [10 August 2010]

Continuing the topic of depression, this week I will focus on the role of omega 3 essential fatty acids. First a correction – of the two Omega 3s it is EPA that is most significant in treating depression, not DHA as stated last week. In fact a study published in 2003 in the Am J. Psychiatry found no benefit to depression with DHA alone.

The largest controlled study to date on the effects of fish oil on depression was published in June of this year in the Journal of Clinical Psychiatry by researchers from McGill U. (Montreal), U. Laval (Quebec City), and Queen’s U. (Kingston). 432 subjects were given 1050 mg of EPA and 150 DHA or a placebo for 8 weeks. For uni-polar depression unaccompanied by anxiety disorder, improvement in depression symptoms was comparable with conventional treatment (without the side effects like sexual dysfunction). There was no improvement, however, in those with anxiety disorder (which supports my argument last week that depression is a complex condition with many factors that need to be addressed).

A previous study in the U.K (Arch. Gen. Psychiatry, 2002) suggests that 1,000 mg of EPA is sufficient. Subjects with depression were given 1g, 2g and 4g of EPA for 12 weeks. The best results occurred in the 1g group with about 75% of the subjects reporting significant improvements in depressive symptoms including anxiety, sleep, libido and suicidal thoughts. Significantly all of the subjects in this study had persistent depression which had not responded to antidepressant drugs.

This large study only confirms the positive results from many previous smaller clinical trials. Long term studies of fish oil supplementation for cardiovascular health have proven their safety. People suffering from depression should ask their physician about adding an Omega 3 supplement to their program.

This article is intended for educational purposes only; for medical advice consult your licensed health practitioner.

074 Depression [3 August 2010]

Depression is a debilitating condition that is very widespread in North America. A group of anti-depressant drugs called SSRIs are some of the most popularly prescribed medications in the United States and Canada. Recent research, however, is questioning both their safety and effectiveness.

A recent (2008) meta-analysis looked at over 50 clinical trials and concluded that the difference in improvement between anti-depressants and a placebo was not clinically significant, with the possible exception of the most severely depressed. And each of these drugs comes with a long list of serious side effects including (to name a few) insomnia, weight gain, fatigue, gastro-intestinal bleeding, Parkinson’s, and an increase in violent or suicidal behavior.

Fortunately there are safer and more effective natural solutions. The following factors need to be addressed with depression:

• Adrenal, thyroid and pituitary glands need to be supported and restored to normal function;
• Omega 3 EFAs from fish oil (especially DHA) are essential for rebuilding the nerve cell membranes so neurotransmitters can function effectively;
• Multi vitamin and mineral supplementation to reverse possible vitamin and trace mineral deficiencies;
• L-tryptophan and St. John’s Wort are safe and effective temporary measures to increase serotonin levels while the glands are being restored;
• Daily exercise is a simple way to boost serotonin levels.

People suffering from depression experience hopelessness and despair. I’m pleased to tell them there is hope, and that with a little effort the sun can shine once again in their life.

This article is intended for educational purposes only; for medical advice consult your licensed health practitioner.