466 Live Longer with K2 [9 Apr 2018]

In the heart health protocol discussed in #464 last month, an important nutrient was left out – vitamin K2.

I previously described the importance of K2 for moving calcium into the bone instead of our arteries and joints, thus preventing both osteoporosis and arterial calcification. Everyone taking a calcium supplement should be taking vitamin K2 and vitamin D (better calcium supplements have both included in the formula). But recent research is finding that vitamin K does more – it also reduces our risk of diabetes and certain cancers, helping us to live longer.

A 2014 study published in J Nutr of over 7,000 adults over 4-5 years concluded “An increase in dietary intake of vitamin K is associated with a reduced risk of cardiovascular [57%], cancer [28%], or all-cause [26%] mortality in a Mediterranean population at high cardiovascular disease risk.”

Both vitamins K1 and K2 have been found to reduce the risk of diabetes. The K2 dependent protein osteocalcin, which moves calcium into the bones, also increases insulin sensitivity. One study found that K2 reduced the risk of type 2 diabetes by7% for each 10 mcg increased intake.

Recent research has found vitamin K2 strongly protects against liver, prostate and colon cancer. Vitamin K2 induces cancer cell death in several ways and suppresses tumor growth. In a 2006 study of liver cancer patients, 45 mcg daily of vitamin K2 after 3 years reduced the recurrence rate from 91% to 64% and increased the survival rate from 64% to 87%, compared to the control group.

Back in June 2015 [#323] I showed that taking statin drugs for lowering cholesterol also inhibits the synthesis of vitamin K2. I just learned that some anticoagulant drugs such as Coumadin (Warfarin) also inhibit the action of K2, resulting in increased calcification of arteries. Adding a low dose of K2 to the program – under your doctor’s supervision – may reduce this side effect while maintaining the anticoagulant effect. Your doctor will need to adjust the dosage of the drug to compensate.

Vitamin K2 will not only keep your bones strong and your arteries clean but will protect you from diabetes and cancer, helping you live a longer healthier life.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

323 Statins & Vitamin K2 [15 June 2015]

Back in April 2012 I wrote about the effect of statin (cholesterol lowering) drugs on Co-enzyme Q10 and muscle pain [#159]. Later, in December 2014 [#299] I showed that vitamin D along with CoQ10 relieves statin-induced myalgia (SIM). In the conclusion I wrote “If I was taking a statin drug, in addition to supplementing with Q10, I would make sure my D levels were adequate”. New research indicates that statin users should add K2 to their list of supplements as well.

A recent discovery, discussed by Okuyama et al in the March 2015 Expert Review of Clinical Pharmacology, is that statin drugs inhibit the synthesis of vitamin K2. I have previously discussed [#149] how K2 is essential for directing the calcium from your diet and supplements into your bones instead of your joints and arteries. A 2009 study from Utrecht, Netherlands, had shown that a high intake of K2 reduced the risk of coronary heart disease. It now appears that, ironically, statins, by inhibiting K2 synthesis, could be promoting atherosclerosis, the very condition they are supposed to prevent. The same study (Okuyama et al, 2015) added that statins also inhibit the synthesis of glutathione peroxidase, the essential antioxidant I discussed in two columns in May. Another study published in June 2011 in JAMA concluded that high dose statin therapy increases risk of diabetes compared to moderate dose therapy.

How could it be possible for drugs with side effects like these to be so popular (taken by 1 in 4 Americans age 45 and over)? Are the benefits really worth the risks? An investigation into this question was published by Diamond & Ravnskov in the same March 2015 issue of Expert Review of Clinical Pharmacology. They conclude:

“…although statins are effective at reducing cholesterol levels, they failed to substantially improve cardiovascular outcomes… Statin advocates have … [deceptively amplified] the trivial beneficial effects of statins [and] succeeded in minimizing the significance of the numerous adverse effects of statin treatment.”

Please follow the links below, and read these articles for yourself. Then discuss them with your physician and pharmacist. If you decide that statin therapy is still indicated, then consider supplementing with CoQ10, and vitamins D and K2.

Sources:

Okuyama, H et al Expert Rev Clin Pharmacol 2015 Mar:8(2):189-99 Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms [abstract]

Gast, GC et al Nutr Metab Cardiovasc Dis 2009 Sep:19(7):504-10 A high menaquinone intake reduces the incidence of coronary heart disease [abstract]

Diamond DM, Ravnskov U. Expert Rev Clin Pharmacol 2015 Mar:8(2):201-10 How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease.[abstract]

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

319 Increasing Glutathione – Who Can Benefit? [18 May 2015]

Last week (#318) I showed you how to raise your glutathione levels. Which brings up the question of who would benefit from increasing glutathione.

In medicine we think of one drug for one disease, and are taught to be skeptical of “panaceas” that promise everything. But in natural healing many different nutrients must work together to improve one condition; and a single nutrient can improve many different conditions. Glutathione is a perfect example of the latter because its powerful antioxidant properties make it essential for health in every cell of the body.

You could benefit from increasing glutathione levels if you:
• want to look and feel younger – as we age our bodies produce less glutathione
• are an athlete – improves strength, endurance and reduces recovery time
• are a smoker, welder, mechanic, chemical farmer, consume alcohol, or are otherwise exposed to chemical toxins – protects your organs from damage
• use a cell phone or WIFI, are exposed to microwaves or ultraviolet radiation – protects cells from radiation damage
• have a chronic disease like asthma, Alzheimer’s, Lupus, Parkinson’s, arthritis, macular degeneration – all associated with low glutathione
• are fighting a viral infection such as a cold, hepatitis, herpes, bronchitis, pneumonia, even AIDS – strengthens the immune system to fight infections
• have impaired or diseased organs including heart, liver, kidneys, prostate, stomach, intestines, colon – all benefit from increased glutathione
• have atherosclerosis (risk for heart attack & stroke) – prevents lipid peroxidation and plaque formation
• are healing from trauma – promotes growth of healthy new tissue
• want to sleep better – promotes better more restful sleep
• are sick and tired of feeling sick and tired – supports mitochondria to produce more energy
• are healthy and want to stay that way – helps prevent all above conditions

Sources:
Immunotec website
Nutraxis website

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

270 Atherosclerosis & Vitamin C [2 June 2014]

Among his many accomplishments, Linus Pauling developed a theory and treatment for atherosclerosis – the formation of artery plaque.

Pauling believed that cardiovascular disease begins with a vitamin C deficiency. Vitamin C makes up an integral part of cell walls, including blood vessels, and a deficiency weakens the walls making them more susceptible to damage. Damaged vessel walls are repaired with deposits of plaque which can build up and eventually impair blood flow to the heart.

Plaque is composed of many substances including fibrinogen, cholesterol, lipoproteins and other fatty molecules. A specific lipoprotein, LPa, acts as the glue to hold the plaque to the artery walls. Receptor sites for the amino acids lysine and proline on the LPa molecules account for its stickiness.

Pauling’s treatment was high doses of vitamin C (he preferred ascorbic acid over ascorbates) and the amino acids lysine and proline. Vitamin C increases the strength of the blood vessel walls, preventing further damage, and also prevents lipid peroxidation and LDL oxidation which contribute to atherosclerosis. The two amino acids fill the LPa’s receptor sites making them less sticky and also help vitamin C with collagen production, necessary for strong blood vessel walls. This protocol not only prevented atherosclerosis from getting worse but after about a year on the program began to reverse it as the amino acids broke up the plaque and the vitamin C repaired the damaged artery walls.

Pauling’s therapeutic protocol used very high doses: 10-18 g daily of ascorbic acid (to bowel tolerance), 5-6 g of lysine and 2 g of proline. Dr. Gifford-Jones’ formula (Medi-C Plus), based on Pauling’s protocol, uses 2-4 g vitamin C and 1.3-2.6 g lysine. This may still seem like a high dosage but it’s not really. I have previously written about vitamin C (#33 Vitamin C & Immunity) – how most animals except humans and apes are able to produce their own C and do so in much higher quantities than we can supplement. A 1993 study from the Research Institute at the Toronto Hospital for Sick Children showed that the daily requirement for lysine – from diet & supplements – is 37 mg per kg body weight (at 90kg I would need 3364 mg or 3.4g lysine).

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

264 Omega-7 a beneficial fatty acid [21 April 2014]

Omega-7 is a family of mono-unsaturated fatty acids of which palmitoleic acid is the most common. I first wrote about this nutrient two years ago in an article on Seabuckthorn.

Recent research (mostly animal studies so far) has found this oil to have many benefits:
• promotes burning of body fat for energy
• improves blood lipid levels (cholesterol)
• prevents atherosclerotic plaque by keeping artery walls smooth and non-sticky
• reduces C-reactive protein, a measure of inflammation
• increases insulin sensitivity thus helping to prevent metabolic syndrome
• protects insulin-secreting pancreatic beta cells
• beneficial for the mucous membranes of the digestive, urinary and reproductive systems
• promotes growth of healthy skin, hair and nails
• supports wound healing

Omega 7 is abundant in only a few foods: Seabuckthorn berries, macadamia nuts, and some cold water fish like anchovies and wild salmon. It is available in supplement form as Seabuckthorn berry oil and in so-called “Purified Omega-7” oil made from fish.

Michael Roizen, MD promotes supplementation with the “purified omega-7” which is free of palmitic acid. This is important, he claims, because palmitic acid, found in Seabuckthorn oil, increases inflammation. The Seabuckthorn promoters counter that this is just a marketing ploy and that palmitic acid, especially in small amounts along with other fatty acids, is actually beneficial. And they remind us that Seabuckthorn is still the richest known source of omega-7.

Other scientists like Irena King, PhD of the U. of New Mexico advises caution in the use of any omega-7 supplement: “I think we’re way too early for supplements of omega-7—way too early. The studies haven’t figured it out yet.” Instead she suggests simply including macadamia nuts in your diet.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

244 Cholesterol & Saturated Fat [25 Nov 2013]

A few weeks ago (#241 “Fatheads” column) I discussed the importance of good fats for brain health and assured you that you would not be trading a reduced risk of Alzheimer’s for a higher risk of heart disease. Since North Americans have been bombarded with the message of “artery-clogging saturated fats” for 60 years (my entire lifetime) this merits further discussion.

Critics of the cholesterol-saturated-fats-heart-disease theory claim overwhelming evidence that not only are these nutrients not the cause of heart disease, but they are essential for good health including heart health. Here are a few of the studies they cite (source: mercola.com):
• A 2010 meta-analysis found no difference in risk of heart disease and stroke between people with the lowest and highest intakes of saturated fat
• The Framingham Heart study found that those with higher intake of saturated fats and cholesterol actually had lower serum cholesterol and body weight
• A 2010 article in Am J Clin Nutr argues that the benefits of reducing saturated fats depend on what replaces it and concludes “dietary efforts to improve the … CVD risk associated with … dyslipidemia should primarily emphasize the limitation of refined carbohydrate intakes and a reduction in excess adiposity.”

In other words replacing fat in your diet with refined carbohydrates will, as I’ve explained before, lead to insulin resistance, obesity, diabetes, hypertension, high serum triglycerides & LDL cholesterol, and ultimately heart disease. The best way to reduce your risk of cardiovascular disease is to reduce refined carbohydrates and maintain a healthy weight. And saturated fats can safely play a larger role in that plan.

A good source of information on cholesterol is the website cholesterol-and-health.com by Chris Masterjohn PhD. He explains the problems with the lipid hypothosis and describes the newer “Oxidized LDL” theory which more accurately models the formation of atherosclerosis. The war on cholesterol (and saturated fat) has been misguided at best. As Masterjohn puts it “the war they are waging is not the path of science. Science is not a war against molecules. It is a search for truth.”

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

237 Bioidentical Hormone Safety [7 Oct 2013]

Back in July (#225 “Preventing Post-Menopausal Fractures”) I mentioned the benefits of bioidentical hormone replacement. This week I want to explore the safety of bioidentical hormones, as the recent publicity over hormone replacement therapy side effects may cause some women – and their physicians – to avoid it.

A review of the medical literature on the subject by Dr. Kent Holtorf MD was published in June 2007 in the Townsend Letter. In it Dr. Holtorf explains that natural bioidentical hormones are very different from the synthetic hormones (made from horse urine or synthesized in a lab) and do not have their serious side effects.

While the 2002 WHI study found that synthetic hormones, particularly the synthetic progesterone MPA, increased the risk of heart attack and stroke, natural estrogen and progesterone have the opposite effect of actually reducing the risk of these cardiovascular diseases. Long term use of both estrogen and synthetic progesterone increase the risk of breast cancer. Natural hormones, particularly estriol and progesterone, lower the risk of breast cancer.

Holtorf also comments from his own professional experience that women on the natural hormones feel great and are more satisfied than women on synthetic hormones. Jeffrey Dach, MD explains the importance of balancing hormone levels on his website. He claims that age-related hormone imbalance is at least partially responsible for most of the degenerative diseases of aging: osteoarthritis, osteoporosis, cardiovascular disease, cognitive dysfunction (Alzheimer’s), loss of libido, and depression.

Ideally all of the hormones should be measured and balanced – estrone, estradiol, estriol, progesterone, testosterone and DHEA – not just one or two. It takes all of your hormones, in balance, to keep you healthy. Periodic hormone testing is also important to ensure that your hormones stay in balance. For more information on bioidentical hormones, contact Cindy Johns at 306-463-4565.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

220 Red Meat & Heart Disease [10 June 2013]

Have you heard about the recent study connecting red meat with heart disease? Briefly the theory holds that carnitine, an amino acid found in red meat, is converted in the intestine to trimethylamine oxide (TMAO) by bacteria found in omnivores (people who regularly eat meat) but not in vegetarians. High blood levels of TMAO had previously been correlated with atherosclerosis, providing a new explanation for red meat as a risk factor for heart disease (besides its content of saturated fat and cholesterol).

Well, don’t swear off steaks just yet. The New York Times article questions whether the association between high TMAO levels and heart disease is cause & effect (i.e. will lowering TMAO reduce your risk?) and concludes “the study does not mean that red meat is entirely bad or that it is best to avoid it entirely…”

Chris Masterjohn, writing for the Weston A. Price Foundation, critiques this study raising other questions and objections:
• a 1999 study showed that beef did not generate significantly more (and often less) TMAO than most other foods including chicken and pork; vegetables such as carrots, cauliflower, peas, and tomatoes; and milk, eggs and bread
• the only foods in the 1999 study which produced significantly more TMAO than beef (up to 100 X higher!) was seafood, which of course is known to lower the risk of heart disease
• the steak eating experiment studied only 5 people – one vegan and 5 omnivores – and the results were too varied to draw any firm conclusions
• numerous studies have shown that carnitine supplementation is beneficial to patients with heart disease
• finally, the whole premise of red meat and heart disease is debatable. Masterson writes “…the balance of epidemiological evidence fails to show an association between fresh, unprocessed red meat and heart disease.”

So don’t give up your steaks yet, at least not based on this study.

Sources:

original article
"Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis" Nat Med. 2013 May;19(5):576-85

New York Times article
Culprit in Heart Disease Goes Beyond Meat’s Fat" New York Times, Gina Kolata, 7 April 2013

Weston A. Price Foundation - critique
Does Carnitine From Red Meat Contribute to Heart Disease Through Intestinal Bacterial Metabolism to TMAO? Chris Masterjohn, 10 April 2013

Mercola.com article - more on the subject
Will Eating Meat Really Increase Your Risk of Heart Disease? 22 April 2013

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

189 Antioxidants & Heart Disease [29 October 2012]

Antioxidants are certain vitamins, minerals and other molecules that protect the body from oxidative stress from highly charged molecules called free radicals, more technically called “reactive oxygen species”. Oxidative stress is believed to be a factor in the development of atherosclerosis – plaque formation in the arteries – and therefore heart disease, but is not generally accepted in North America. A recent study from Israel should increase the popularity of antioxidant therapy as an adjunct for the treatment of vascular heart disease.

The study, published in Nutrition & Metabolism in July 2010, followed 70 adults with at least two of these risk factors: smoking, Type 2 diabetes, hypertension, low HDL cholesterol, or high triglycerides. They were examined after 3 and 6 months. Half of the participants received daily antioxidant supplements containing 1,000mg vitamin C, 400iu vitamin E, 120mg coenzyme Q10, and 200mcg selenium; the other half a placebo. Those taking the antioxidants, but not the control (placebo) group, had the following benefits:
• significant increase in elasticity of both large and small arteries
• significant increase in HDL-cholesterol (the good kind)
• a small decrease in triglycerides
• significant reduction in HbA1C (a measure of long term blood sugar levels)
• reduced blood pressure

Although the study was too small in number of participants and too short in duration to measure risk of heart disease, all of these improvements would be expected to prevent heart attacks and deaths. The authors conclude that the findings of the study “justify investigating the overall clinical impact of antioxidant treatment in [patients with multiple cardiovascular risk factors]”. But if you have some of these risks, you don’t have to wait for more studies before using antioxidants to improve your own health. Ask your doctor or pharmacist if you can add these antioxidants to your current medications.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.