494 Nitrates and Mania [22 Oct 2018]

A connection between nitrates in processed meats and mania has been accidentally discovered. Mania is a psychiatric disorder associated with hyperactivity, euphoria and insomnia. The link appears to be the effect of nitrates on gut bacteria.

I have previously written about the connections between gut bacteria and brain function [#320 Our Gut Microbiome & Our Brain; #422 The Brain-Gut Axis; #425 Autism and Gut Bacteria].

The nitrate connection was discovered in a study by Johns Hopkins published this July in Molecular Psychiatry. The study of more than 1000 people found that those hospitalized for an episode of mania were 3.5 times more likely to have eaten nitrate-cured meats prior to hospitalization. This finding was statistically significant. No association with other foods or other psychiatric disorders were found.

Animal studies were conducted to follow up on this association. Rats fed the equivalent of a human eating a wiener or one stick of beef jerky daily developed hyperactivity and sleep disorders within two weeks. The control group, fed the same food but nitrate free exhibited normal behavior. Differences were found in the bacteria living in their intestines, and in molecular pathways known to be implicated in bipolar disorder. It would appear that the nitrates change the gut microbiome which affects brain function triggering mania in susceptible individuals.

The same research group had published a study in 2017 with the finding that a probiotic supplement reduced the incidence of delusions and hallucinations in schizophrenic patients. They were also less likely to be rehospitalized following a manic episode. The study was too small to recommend it as a treatment just yet, but it does provide more evidence for the influence of the gut microbiome on mental health.

One of the researchers, Emily Severance, assistant professor of pediatrics at the Johns Hopkins University School of Medicine, wrote:

The mental health field is in desperate need of new treatments for psychiatric disorders… The tiny living organisms that make up the human microbiome and the overwhelming evidence for a gut-brain axis together represent a new frontier for schizophrenia research.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

476 The Schizophrenias [18 June 2018]

In his book Nutrient Power – Heal Your Biochemistry and Heal Your Brain, William J. Walsh refines Carl Pfeiffer’s biotypes of schizophrenia, and describes each in some detail as to symptoms, chemistry, and their nutrient therapy.

Walsh’s schizophrenia biotypes are (with % of occurrence):
• Overmethylation (42%)
• Undermethylation (28%)
• Pyrrole disorder (20%)
• Gluten intolerance (4%) – see Grain & Our Brain [#240 Oct 2013]
• Other (6%) – porphyria, cerebral allergy, polydipsia, thyroid deficiency; homocysteinuria and drug-induced.

The overmethylated biotype is the most common. It is characterized by auditory hallucinations, severe anxiety, paranoia, hyperactivity and depression, and is often diagnosed as paranoid schizophrenia. Signs include elevated serum copper, low blood histamine, and low basophil count; with high dopamine and norepinephrine activity. Patients often have an adverse reaction to SSRI drugs or SAMe, but improve with benzodiazepines and lithium. Biochemical therapy includes zinc, manganese and vitamins B10 (folic acid), B3 (niacin), B6, B12, C and E.

The undermethylated biotype is characterized by delusions, OCD, high anxiety, and catatonic behavior, and is usually diagnosed as schizoaffective disorder or delusional disorder. Signs include low methyl/folate ratio, high histamine (subject to seasonal allergies), high basophil count, and low SAMe/SAH ratio; with low activity of serotonin, dopamine and norepinephrine. Patients respond well to SSRIs and antihistamines but not to benzodiazepines or folic acid. Biochemical therapy includes SAMe, methionine, calcium, magnesium, zinc, serine and vitamins A, B6, C, D and E.

The pyrrole disorder biotype (also called “Mauve” from the purple color of urine) is characterized by extreme mood swings, severe anxiety, low tolerance to stress, light or noise, and a combination of delusions and auditory hallucinations. A common diagnosis is rapid-cycling bipolar disorder. Signs include very high pyrroles in the urine, severe deficiencies of zinc and B6, deficiencies of biotin and arachidonic acid, and depleted glutathione. Patients exhibit severe oxidative stress and low activity of glutamate and GABA. Biochemical therapy includes zinc, B6, and evening primrose oil.

Biochemical therapy involves high doses of certain minerals, vitamins, and other nutrients, and is different for each biotype. Diagnosis and treatment should only be undertaken by an experienced professional.

Next week – biochemical classification of depression.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner. Find this article on my website for links to sources and further reading.

475 Biochemical Imbalances in the Brain [11 June 2018]

In his book Nutrient Power – Heal Your Biochemistry and Heal Your Brain, William J. Walsh stated that he considers the greatest achievement of Dr. Carl Pfeiffer to be his discovery of different biochemical types of schizophrenia, each with distinctive symptoms and blood and urine chemistries. Pfeiffer had also developed effective nutritional therapies for each biotype. Over the last three decades Walsh refined these biotypes and their biochemical therapies.

Mental health depends on a balance of the neurotransmitters, especially serotonin, dopamine and norepinephrine. Their concentration is largely regulated by special large molecules in the cell membrane called transporters which allow the neurotransmitters to be reused, a process called reuptake. The synthesis of transporters is in turn regulated by the relative amounts of methyl (CH3) and acetyl (CH3CO) attached to the DNA of the respective genes. The methylation and acetylation processes are strongly influenced by the presence of certain nutrients: folate (B10) and niacin (B3) promote acetylation (which enhances gene expression) while methionine and SAMe promote methylation (which inhibits gene expression). Walsh writes:

“After 25 years of searching, we finally have a convincing explanation for the apparent effectiveness of the folate, niacin, and methylation therapies developed by Abram Hoffer and Carl Pfeiffer”.

In addition to over or under-methylation, Walsh observed other biochemical imbalances that occur in unusually high frequencies in many completely different mental disorders: copper overload, B6 deficiency, zinc deficiency, oxidative stress overload, amino acid imbalances, essential fatty acid imbalances (especially DHA deficiency), and toxic overload (heavy metals, pesticides). He realized that what these had in common was playing a role in the synthesis or function of neurotransmitters.

The levels of these nutrients are well-regulated for most people, but genetic or epigenetic abnormalities can result in a deficiency or overload. Walsh found that providing the missing nutrients in appropriate doses, while slower to take effect, worked as well or better than psychiatric drugs but without the undesirable side effects.

Next week – the schizophrenias.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

474 Biochemical Therapy [4 June 2018]

In previous articles on nutrition and mental health [#297 8 Dec 2014 “Mental Health Revolution”; #300 5 Jan 2015 “Medicate or Nutrate?”; and #317 4 May 2015 “Nutritional Psychiatry”] I argued that it was time for another revolution in mental health treatment. A recent book by William J. Walsh (revised 2014), Nutrient Power – Heal Your Biochemistry and Heal Your Brain, indicates that this revolution is well on its way.

Walsh worked closely with Dr. Carl Pfeiffer, a pioneer in nutritional treatment of mental illness and the first to recognize that there were different biochemical types of schizophrenia (in my personal reference library I have a 1970 copy of Pfeiffer’s book The Schizophrenias, Ours to Conquer). Walsh went on to refine both the diagnosis and nutritional treatment (which he calls biochemical therapy) of mental illness based on recent research. His book Nutrient Power summarizes many decades of research and tens of thousands of cases.

Brain biochemistry is highly complex. More than 100 different neurotransmitters are active in the brain, and mental health depends on their proper function at the nerve synapses. Each neurotransmitter depends on numerous nutrients for its synthesis and function. Special proteins called transporters embedded in the nerve cell membranes allow the neurotransmitters to be reused. Epigenetics – inheritable environmental factors which control gene expression – plays a critical role in the production of neurotransmitters and transporters. The presence or absence of certain nutrients or toxins turns on or off the genes which produce these critical proteins.

Walsh cautions readers not to try this therapy without supervision by an experienced medical professional. There are many different biochemical imbalances which cause mental illnesses, and specific tests and history analysis are required to determine which are involved and therefore which treatment to use. Too much of a nutrient, for example folate, can be as harmful as not enough. In Walsh’s words:

The challenge is to carefully identify the specific nutrient overloads and deficiencies possessed by an individual and to provide treatments that normalize blood and brain levels of these chemicals with rifle-shot precision. This is the essence of biochemical therapy.

I find this book fascinating and will share more from it in coming weeks.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

445 Methylfolate [6 Nov 2017]

Folate is a B vitamin (B9) with many essential roles in our metabolism. It is found in leafy green vegetables, hence the name folate after “folium”, Latin for leaf. Folate is also synthesized by certain lactobacillus and bifidobacteria bacteria in our small intestine.

Most of us have heard that folate is essential in pregnancy to prevent the birth defect spina bifida, but it plays many other roles. Folate:
• is essential in cell division and synthesis of DNA and RNA
• helps make the neurotransmitters serotonin, dopamine, and norepinephrine
• prevents neural tube defects (including spina bifida) in pregnancy
• helps prevent anemia in pregnancy
• converts homocysteine to less-toxic methionine (homocysteine increases inflammation and risk of heart disease)
• maintains healthy T cell production and therefore resistance to infections
• improved symptoms of depression, bipolar and schizophrenia
• improves cognitive function and slows brain deterioration in Alzheimer’s and dementia

The natural form, folate, is metabolized in the small intestine to the active form methyltetrahydrofolate (MTHF). The synthetic form, folic acid, found in “fortified” foods and cheaper vitamin supplements, requires conversion in the liver before a final conversion to THF. The liver process requires an enzyme, MTHFR, of which many people have inherited an inactive form. These people are unable to utilize folic acid or even some of the natural forms found in food. If they supplement with folic acid toxic levels could build up in their livers, so they need to use the methyl form. Are you one of them? Genetic testing could tell you – but a trial with MTHF would be easier and cheaper.

The ubiquitous herbicide glyphosate preferentially kills the folate producing bacteria in our gut so now it’s even more essential to get folate from our diet and supplements.

Similar to methylcobalamin being the preferred form of vitamin B12 [see #339], the preferred form of B9 is methyltetrahydrofolate. I’ve noticed recently that more of the higher quality B complex and multi vitamins have these forms of B9 and B12. Look for them when you are buying vitamins for yourself and your family.

Sources for further reading
- Mercola.com
- SelfHacked.com

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

438 Nutrients for Mental Health

One in five Canadian adults are on a prescription drug for a mental health problem. The most common – depression, anxiety and insomnia – frequently occur together. Nutritional supplements can greatly benefit people with these mental health issues. The protocol varies slightly depending on whether they are on a prescription or not.

For those already on a mental health prescription, the following have proven beneficial and completely safe:
• Fish oil with high EPA (e.g. 1000 EPA, 200 DHA)
• Vitamin D 2,000 IU (more if blood levels low)
• Good multi or B complex with bioactive form of B vitamins
• Melatonin (adjust to individual need)

For those not on prescription meds, use the same fish oil and vitamin D with these additional natural products:
• Melatonin or an herbal/nutrient sleep aid
• Anti-stress and mood elevating formulas that may include: bioactive B vitamins, choline, & inositol; amino acids L-theanine, L-tryptophan, PABA, 5-HTP, GABA, & SAMe; and botanicals like ashwagandha, valerian, passionflower, rhodiola & holy basil.

Be cautious with herbs if you are taking a prescription drug as they can affect the rate of drug processing by the liver and change the drug’s effective potency.

The ratio of EPA to DHA in fish oil is critical. For almost all situations, oils with higher EPA (at least 2:1) work better, especially for mood. Oils with higher DHA have been shown to worsen mood and aggression. This holds for children with ADD – the high EPA formulas help; the high DHA ones do not, and could worsen symptoms.

Omega 3 fish oil is often under-supplemented. At low doses (250-900 mg total EPA+DHA) it is has been shown to reduce the risk of sudden coronary death. But at higher doses (2,000-4,000 mg) it also reduces risk of non-fatal coronary events (angina); improves blood lipid values (triglycerides & cholesterol); and reduces pain and inflammation (arthritis, etc.). 1000-3000 mg of 2:1 EPA:DHA is ideal for neurodegenerative conditions like dementia, Alzheimer’s, Parkinson’s & MS.

Source: "Mental Health" webinar by Philip Rouchotas MSc, ND, September 11, 2017, sponsored by New Roots Herbal

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

422 The Brain-Gut Axis [29 May 2017]

Last week we looked at how our gut microbiome affects our immune system. This week we’ll discuss how it affects our brain, mood and memory. I last wrote about this topic two years ago [#320]. The network of neurons and chemical pathways connecting the digestive tract and the central nervous system is called the Brain-Gut Axis.

The brain uses this axis to monitor the digestive tract for hunger, stress, and the presence of pathogens; and to control aspects of it, including transit speed, production of mucous lining the colon, and the secretion of stomach acid, bile and pancreatic enzymes. But the signaling goes both ways – the condition of the digestive tract, including the bacteria living in it, also influences the brain.

Justin and Erica Sonnenburg in their 2015 book The Good Gut devote a chapter to this connection and share findings from some of their animal experiments. Lab mice specially raised to have a bacteria-free gut lacked the caution that helps wild mice avoid predators, and scored lower in memory tests than mice with normal gut microbes. Other experiments showed that transplanting gut bacteria from anxious mice to calm mice increased their anxiety (and vice versa) along with measurable changes in their brain biochemistry.

One way that the gut bacteria influence the nervous system is by the chemicals they produce which get absorbed into the bloodstream. Some of these chemicals have a beneficial effect like the short chain fatty acids mentioned last week. An estimated 90% of our serotonin, the “feel-good” neurotransmitter, is produced in our gut with the help of certain bacteria. Other bacteria-produced chemicals are toxic and have undesirable effects. An example is EPS, which was found to be greatly elevated in mice with autistic-like behavior; the behavior improved when different bacteria were introduced which normalized the EPS levels.

Research holds the promise of modifying our microbiome in the treatment of not only inflammation related chronic diseases like MS and Inflammatory Bowel Disease (IBD), but also mood disorders like stress, anxiety, depression, and even neurological conditions like autism, ADHD, OCD, and schizophrenia. This is one field of research that I plan to keep an eye on. More next week.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

392 Brain Supplements [24 Oct 2016]

I have written many times about brain function and memory. In August 2015 I listed 10 diet and lifestyle changes to help prevent loss of brain function [#333 Preventing Alzheimer’s]. To complement that list, this week I will list 5 supplements that support mental health. It’s based on an article in this month’s Vitality Magazine by Amanda Burke, CNP, called “Brain Food – My Five Favourite Supplements for Mental and Emotional Health”.

Amanda writes:

Thanks to great research in the area of nutritional medicine it is now known that good brain nourishment can not only prevent many of the health related issues associated with mental decline…and stack the odds in their favour for prevention of age-related, inherited, and environmentally-induced mental decline, but they can potentially reverse the brain’s biological age and access abilities like never before.

Her five favourite brain supplements are:
• High dose Probiotic – a healthy gut microbiome is essential for good mental health [see #320 Our Gut Microbiome & Our Brain] and a good therapeutic-dose probiotic helps restore a healthy population of beneficial gut bacteria
• Serrapeptase – reduces inflammation and helps heal leaky gut syndrome which can affect brain function [see #217 Serrapeptase]
• Curcumin – protects the brain by reducing inflammation and blocking plaque formation [see #384 Curcumin & Alzheimer’s]
• Magnesium L-Threonate – the magnesium that crosses the blood-brain barrier for optimal brain function [see #350 Magtein – Magnesium for the Brain]
• B-Complex – B vitamins are essential for brain function (memory and clear thinking) [see #157 Vitamin B12 & Your Brain and #390 The B Vitamins]; a high dose coenzyme formula is most effective along with herbs like ashwagandha, rhodiola [see #39 Rhodiola rosea], and ginseng to help manage stress

To Amanda’s list I would add Vitamin D [see #336 Alzheimer’s & Vitamin D], an Omega 3 with high DHA [see #194 Fish Oil & Your Brain], and perhaps phosphatidyl serine [#248 Phosphatidyl Serine]. In developed cases of Alzheimer’s coconut oil or the concentrated MCT oil provides an alternative energy source for the brain when it can no longer utilize glucose [see #153 Alzheimer’s and Coconut Oil].

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

350 Magtein - Magnesium for the Brain [21 Dec 2015]

In March, April & May of 2013 I wrote three columns on magnesium and its many important roles in human health. The May column was about magnesium bisglycinate, a new non-laxative form of this mineral. This week I’m writing about another new form of magnesium and its amazing benefits for mental health.

Magnesium plays essential roles in brain function and in the repair of injured brain tissue. Magnesium deficiency has been linked to confusion, fatigue, irritability, poor memory, and reduced ability to learn.

The problem is that most forms of magnesium do not readily cross the blood-brain barrier and are therefore ineffective in raising magnesium levels in the cerebral spinal fluid (CSF). The only exception is magnesium L-threonate which was recently developed by MIT researchers. An animal study showed that Magtein (the patented brand name of magnesium L-threonate) outperformed all other forms of magnesium in raising CSF levels; in fact it was the only form to significantly raise magnesium levels.

Along with the increase in CSF magnesium levels, animal studies have shown Magtein to improve long and short term memory and to enhance learning abilities. Both young and older animals improved spatial working memory on maze tests.

A decline with age in synaptic connections in the hippocampus part of the brain is correlated with impaired memory and Alzheimer’s disease. In animal studies Magtein supplementation increased the synaptic density in the hippocampus.

Magtein supplementation significantly reduced Beta amyloid plaques, associated with Alzheimer’s disease, in Transgenic Alzheimer’s (TA) mice. Even older end-stage TA mice showed reduced plaque and significant improvement in memory tests, providing hope for Magtein as a treatment for advanced Alzheimer’s.

Human clinical trials are under development to see how well Magtein works in people. Meanwhile Magtein has been available in the US for several years and has just been approved for sale in Canada. People using Magtein report noticing changes in anywhere from a few days to a few weeks. Some of the benefits reported are: improved memory, restored ability to think and focus, brain fog cleared, improved mood, better quality sleep with vivid dreams, less need for afternoon naps, and increased energy. An 81-year-old summed it up this way “It is a marvelous feeling to have my mind back again!”

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner. See this article on my website for links to sources and further reading.

322 The Gut Microbiome Diet [8 June 2015]

Two weeks ago (#320) I discussed how our gut microbiome (the bacteria in our intestines) affects our brain health, specifically mood disorders like depression; diabetes and obesity; and neurological disorders like autism, ADHD, Parkinson’s, MS and Alzheimer’s. I ended by hinting that changing our diets can quickly change our gut microbiome and reduce the risk of these conditions.

How can we best do this?

1. First, avoid unnecessary antibiotics.

2. Restrict sugar, especially fructose, which promotes dysbiosis (growth of unhealthy bacteria).

3. Replace processed foods with whole raw foods wherever possible.

4. Add probiotic foods to your diet – fermented vegetables, sauerkraut, kimchi, kefir, yogurt, and kombucha tea. These must be unpasteurized and preferably home-grown. I’m looking for sources of starter cultures for these foods – can anyone help me out here?

5. Eat plenty of prebiotic foods which provide fiber for the good bacteria to thrive on. Whole, raw vegetables are best, as cooking destroys some of the fiber. Good sources are:
• Jicama, chicory root and Jerusalem artichoke contain inulin, an excellent prebiotic fiber
• dandelion greens, asparagus
• cooked yams, sweet potatoes, potato skins
• root veggies (may be cooked): carrots, turnips, parsnips
• raw onions, leeks, garlic
• cooked legumes: beans, peas, lentils, chick peas
• raw or cooked cabbage, broccoli and cauliflower
• avocado, apples, and bananas
• wheat bran, soaked or cooked whole wheat.

If you make a good effort to make some of these changes, you should notice an improvement in your digestive (and mental) health within a few weeks. Caution – some of these changes, like introducing more legumes and cabbage, need to be made gradually.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

317 Nutritional Psychiatry [4 May 2015]

Nutritional psychiatry (NP) is a branch of science that uses nutrients to treat psychiatric symptoms and mood and anxiety disorders. Bonnie Kaplan is a professor at the U. of Calgary and a researcher in nutritional psychiatry. A recent interview with Kaplan for the Economic Times was published online March 20, 2015, as “Nutritional psychiatry can be an effective treatment”.

In the interview, Kaplan made these six points:

1. NP is a new science, less than 15 years old. Kaplan is researching the use of a broad spectrum nutrient formula to treat psychiatric symptoms and mental disorders.

2. NP is effective because normal brain function requires micronutrients. Mental illness can result if any nutrients are in insufficient supply. In one case study a young boy with bipolar disorder who was regressing (getting worse) during six years of conventional treatment, was completely cured after 14 months with nutritional treatment.

3. Many psychiatrists are opposed to nutritional psychiatry. They are trained in drug therapy and are uninterested in normal brain metabolism. Government funding is difficult to obtain because of the lack of support by conventional medicine.

4. Pharmaceutical companies are not interested in NP because it is less profitable. In another case study, a young boy suffering from severe psychosis had been treated conventionally with no improvement, then successfully treated with nutritional therapy at less than 1% of the cost.

5. NP cannot always totally replace drugs; in some cases it complements drug therapy. Kaplan believes the ideal situation would be for nutrition to be the primary therapy and medication play a supportive role when needed.

6. NP is not just about supplementation but includes a diet of high quality nutritious food for its vitamin, mineral and phytonutrient content.

To learn more about nutritional psychiatry and the broad spectrum nutrient formula visit www.truehope.com or phone 888-878-3467.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner. See this article on my website for links to sources and further reading.

316 Stress & Anxiety [27 April 2015]

Stress is defined as the non-specific response to change, which often affects mental and physical health. Stress is unavoidable and some stress is in fact essential to life. Where it becomes a concern is when chronic stress keeps us in the “fight or flight” response 24/7.

Chronic stress is a factor in almost all disease – particularly physical conditions like muscle tension, pain, and fatigue, and mental or emotional conditions like depression, OCD, and anxiety. Natural health products have been formulated to manage the stress response before it causes mental or physical disease. These include ingredients like:
• Melissa (lemonbalm) – increases GABA in the brain
• Rhodiola – moderates neurotransmitter activity
• Ashwagandha – reduces the amount of cortisol needed for stress response
• L-theanine – promotes mood balance and relaxation, increases alpha brain waves
• Choline – precursor for many neurotransmitters
• Inositol – modulates serotonin activity in the brain
• 5-HTP – supports theanine in mood regulation

Anxiety is a mental health condition which is often a reaction to stress. The normal emotions of worry and fear take over our lives and lead to mental and physical symptoms. The first natural health product licensed by Health Canada specifically for anxiety includes:
• Passionflower – relieves feelings of anxiousness
• Ashwagandha – reduces stress and nervousness
• L-theanine – promotes relaxation, reduces tension & anxiety
• American ginseng – supports brain function and memory
• Holy basil – improves resistance to stress

Why let stress and anxiety take over your life when you can manage them safely and effectively with all-natural products.

Source: www.veeva.ca

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

300 Medicate or Nutrate? [5 Jan 2015)

For my 300th article (and the first for 2015) I’m going to follow up on #297 from Dec 8 on mental health.

Dr. Julia Rucklidge in her TEDx talk suggested we reconsider our current treatment approach to mental illness – psychiatric medication first, followed by psychological therapies, with nutrition as an afterthought (if considered at all). Instead she proposes the first priority be lifestyle factors (healthy eating, exercise, supplements) and when necessary psychological treatment, and save medications for when these approaches prove insufficient.

Anthony Stephan, founder of TrueHope, argues that it’s better to nutrate our brains than to medicate them. He prefers to call mental illness “nutritional deficiency mood disorders” and believes that given sufficient nutrients the body can heal itself.

Putting nutrition first makes sense to me. The brain makes up 2% of body mass but consumes 20% of our energy and uses a disproportionately high amount of our daily intake of nutrients. How can we expect it to function properly if our diets are depleted in essential nutrients? Kaplan & Rucklidge in their December 9, 2014 madinamerica.com article “Nutrient Boosting of Medications” put it more technically:

...psychiatric symptoms may be the result of inborn metabolic dysfunction associated with slowed metabolic activity caused by insufficient vitamin and mineral cofactors.

Note that nutrient dosages much higher than the RDA are usually required to compensate for these metabolic dysfunctions.

Research on micro-nutrition and mental illness (25 published studies to date) shows positive often dramatic improvements with a broad spectrum high dose nutrient supplementation on a variety of conditions: depression, bi-polar disorder, autism, ADHD, OCD, PTSD, stress, anxiety, mood & behavior, and addiction. Over the last 16 years TrueHope and its micronutrient supplement has helped tens of thousands of people with mental illness return to a normal life and either reduce or eliminate their psychiatric medications. Shouldn’t this be our primary treatment for mental illness: nutrate rather than medicate?

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

297 Mental Health Revolution [8 Dec 2014]

The discovery of the first anti-depressant in the 1950s ushered in a revolution in mental health. This and the families of anti-depressant, anti-anxiety and anti-psychotic drugs that followed not only provided results not possible before but did much to remove the stigma of mental illness. They showed that mental illness is a chemical imbalance, not a character flaw, and not the fault of the person experiencing it.

Unfortunately, recent research is finding that while these drugs have good short term results, the long term can be a different story. Dr. Julia Rucklidge, a clinical psychologist in New Zealand, expanded on this topic in a recent TEDx Talk. She reported huge rates of increases over the past few years in ADHD, autism, bipolar disorder and other psychiatric illnesses in New Zealand and internationally, and then discussed the long term shortcomings of conventional treatments.

Rucklidge has spent the last ten years researching the effects of micro-nutrition on mental health. She and other researchers around the world, have found that the broad spectrum high dose supplement she works with consistently provides superior, often dramatic, results in the short term, without the long term side effects of conventional treatments, for many different conditions including: stress, anxiety, addictions, depression, ADHD, OCD, autism, and Bipolar Disorder. Links to these studies can be found on the TrueHope website. She explains that eating well is essential for mental health but for some people it is not sufficient to turn around a serious mental condition. She also cautioned that the number of nutrients (36) and the dosage used by the researchers are far higher than you would find in a regular multivitamin.

I first wrote about this program in January 2010 "A Discovery of Truehope". Listen to an interview with Truehope founder Anthony Stephan talking about the program and how it came to be.

Rucklidge sums it up this way:

“Poor nutrition is a significant and modifiable risk factor for the development of mental illness… Optimizing nutrition is a safe and viable way to avoid, treat or lessen mental illness.”

I think it’s time for the next revolution in mental health.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

281 Disappearing Microbiota [18 August 2014]

I have written several columns on the many problems associated with dysbiosis (an unhealthy balance of bacteria in the digestive tract) and the benefits of probiotics.
• The obvious problems include digestive disorders like gas, bloating, constipation, and diarrhea [03].
• Upper respiratory infections like thrush, “strep throat”, sinus and ear infections can be prevented by introducing a particular strain of S. salivarius to the mouth [72].
• Infection by a bacterium H. pylori causes stomach ulcers [221].
• Dysbiosis can cause Inflammatory Bowel Disease (IBS) like colitis and Crohn’s which can lead to leaky gut syndrome and food allergies.
• Our immune system [78, 173] is affected by dysbiosis, causing autoimmune conditions like eczema, asthma and rheumatoid arthritis.
• The work of Dr Natasha Campbell-McBride [147, 172] links unhealthy gut bacteria to neurological and psychiatric disorders ranging from ADHD and autism to schizophrenia.
• Dysbiosis can even prevent weight loss.

Now microbiologist Martin Blaser takes this even further in his 2014 book Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues. Modern scientific study of the human microbiome – the thousands of species of bacteria that coexist in or on our bodies – is revealing how critical it is for our health. Blaser writes

“The microbes that constitute your microbiome … play a critical role in your immunity as well as your ability to combat disease. In short, it is your microbiome that keeps you healthy.”

He then makes a convincing case that loss of many of these species is responsible for the recent worldwide proliferation of the “modern plagues” of obesity, childhood diabetes, asthma, hay fever, food allergies, esophageal reflux, certain cancers, celiac disease, Crohn’s disease, ulcerative colitis, autism, eczema, and others.

Blaser believes that the loss of diversity within the human microbiome is an even more serious problem than the antibiotic-resistant super bugs. He calls the problem the “disappearing microbiota” and warns of a coming “antibiotic winter” if the problem isn’t addressed.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

278 Could Probiotics Make You Sick? [28 July 2014]

Probiotics are beneficial micro-organisms taken as a supplement for healthy digestion and many other health benefits, especially following a course of antibiotics (see my posts #78, 172, 173 & 243). But in rare situations probiotics can cause an illness called D-lactate acidosis.

Lactic acid (lactate) is produced by lactobacillus and other types of bacteria in our intestines. There are two forms of lactic acid: L-lactate and D-lactate. Certain bacteria in probiotics like L. acidophilus produce more D-lactate than others. Some people – especially those who have bowel disease or had bowel surgery (short bowel syndrome) – have an impaired ability to metabolize the D-lactate form, resulting in lactic acidosis. D-lactose intolerance is associated with carbohydrate intolerance and leaky gut syndrome.

D-lactate acidosis can also be caused by antibiotics. L Acidophilus is relatively resistant to common antibiotics so may proliferate post treatment.

D-lactic acidosis affects the central nervous system causing symptoms including:
• Weakness and fatigue
• Inability to concentrate
• Agitation, irritability, hostility
• Headache, teeth grinding, involuntary eye movement
• Slurred speech
• Impaired motor coordination, gait disturbance
• Nausea, vomiting & diarrhea

There is a lab test for blood levels of lactic acid to aid in diagnosing this condition. Ironically one treatment is antibiotics. A low carbohydrate diet also helps. Probiotics without L. acidophilus may be helpful if tolerated.

My purpose in sharing this information is not to scare anyone from using probiotics. They are beneficial for almost everyone and essential for many. But should you experience a severe reaction after taking a probiotic, don’t just assume it’s a temporary “die off” reaction from toxins released by dying harmful bacteria. You could be one of the very rare “lucky” people with impaired D-lactate metabolism that require a low carb diet and a special L. acidophilus-free probiotic.

257 Vitamin B12 & Your Brain [3 March 2014]

Do you ever suffer from low energy, brain fog, or moodiness, have trouble sleeping or just feel “yucky”, there’s a good chance you have a vitamin B12 deficiency.

A Tufts university study found that B12 deficiency occurred in nearly 25% of people over 26 and about 50% of people over age 50. Symptoms of B12 deficiency include:
• low energy and weakness
• confusion or “brain fog”
• cognitive decline & memory loss
• sleep problems
• hearing and vision loss
• tingling in the fingers and toes
• dizziness
• irritability or depression
• weak immune system
• severe deficiency can lead to dementia.

An important role that B12 plays is to reduce levels of homocysteine which:
• damages arteries increasing risk of heart disease
• weakens bones
• can cause vision and hearing loss.

Factors contributing to B12 deficiency include:
• Over age 45
• Low stomach acid or use of antacids
• Vegetarianism (best food source of B12 is red meat)
• Consumption of alcohol.

The best form of B12 to take is sublingual (dissolves under the tongue) methylcobalamin. Many experts recommend 1,000 mcg daily for maintenance and up to 15,000 to restore optimum levels. B12 is very safe with no drug interactions or adverse effects, even at very high doses. If you want to think more clearly enjoy more energy, and just plain feel better, try supplementing with methylcobalamin.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner. See this article on my website for links to sources and further reading.

248 Phosphatidyl Serine [23 Dec 2013]

Last week I discussed the uses of phosphatidyl choline in cell membrane function; this week we’ll look at its molecular cousin, phosphatidyl serine (or PS for short) and its role in the brain. Like its choline counterpart, PS is a phospholipid found in the cell membrane, but in much smaller amounts. PS is particularly abundant in nerve cell membranes of the brain where it plays a role in inter-cell communication. Our bodies can create PS from phosphatidyl choline but can also obtain some directly from our food. PS occurs in meat, fish, and organ meats particularly brain, but by far the most abundant food source of PS is soy lecithin. As with phosphatidyl choline, our production of PS decreases as we age which may contribute to a decline in brain function.

Double-blind studies in the USA and Europe have shown that PS supplementation can reverse this trend. Specifically, taking PS has been found to improve short and long-term memory and concentration in people with mild to moderate cognitive dysfunction (it doesn’t help much with more severe dementia). PS has also been shown to improve mood, reduce depression and increase social interaction in older people. Phosphatidyl serine supplements, in dosages of 200mg per day, have been used successfully for children with ADHD. PS has also been used, in higher doses, by athletes to reduce exercise-induced stress and soreness.

Phosphatidyl Serine supplements used to be extracted from bovine brain but since the BSE (mad cow) epidemic manufacturers have switched to making it from either soy or sunflower lecithin. Most of the early studies were done with bovine PS – more recent studies with soy based PS have shown less consistent results.

Because phosphatidyl serine is found in every cell of the body, it is a very safe nutrient with only a few rare, mild side effects. The goal of supplementation is to bring the levels of PS in the cell membranes back to what it was when we were younger. Therapeutic effects are dose dependent. For prevention 100mg per day is recommended; to treat age-related mental impairment 200-300 may be needed. PS is commonly sold in 60 and 100mg strengths.

Sources:
Wikipedia Phosphatidylserine
Web MD PS Overview Information
Web MD PS Uses, Side Effects, Interactions
Soy PS study in Japan
Natural Factors monograph

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

241 We’re All “Fatheads” [4 November 2013]

Last week I discussed the book “Grain Brain” by David Perlmutter, MD which argued “…to a large extent numerous neurological conditions often reflect the mistake of consuming too many carbs and not enough healthy fats”. Last week I concentrated on reducing carbs; this week I want to focus on the other half of the equation – increasing good fats. Perlmutter suggests that up to 75% of our diets should be fat, rather than the current average of 20%.

Our bodies, and particularly our brains, require fat for optimal health. Our brains are 60-70% fat, so if someone calls you a “fathead” they are right – but that’s a good thing because our brains couldn’t function without it. Saturated fats are an essential component of brain cells. Similarly cholesterol is essential for every cell of the body and particularly for the brain. The brain contains 25% of our body’s cholesterol, and it’s there for a reason. Cholesterol is essential for proper brain and nervous system function. It facilitates nerve cell communication and acts as an antioxidant to protect the brain. Vitamin D is essential for brain health and is synthesized in our skin from cholesterol.

So do we have to trade off increased risk of heart disease and early death to enjoy a healthy brain? Fortunately, not at all! The same dietary changes that reduce risk of dementia also lower your risk of heart disease, diabetes, and death. Recent research has found that elderly people with the lowest cholesterol levels are at the highest risk for Alzheimer’s and of death from all causes, while those with the highest cholesterol have a significantly lower risk for dementia.

Good fats include olive oil, butter, coconut oil, nuts, avocado, eggs and fatty fish like salmon. Bad fats to avoid are trans fats and hydrogenated (artificially saturated) fats – the fats found in most processed foods. Cooking oils that have been processed to prolong shelf life are also best avoided. Dr. Perlmutter also recommends an Omega 3 essential fatty acid supplement high in DHA.

Finally, Perlmutter also promotes physical exercise as beneficial for the brain. More on that topic next week.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

180 Nitric Oxide – Say “NO” to Disease [27 August 2012]

Nitric oxide (NO) is a simple molecule – just one atom of nitrogen and one of oxygen – but it plays some very important roles in the body. The discovery of NO’s role in cell communication won a 1998 Nobel Prize. I touched on the functions of NO in my June 11 article (#169) on the amino acid arginine. Here is more information on nitric oxide:

• NO lowers blood pressure by relaxing the smooth muscles of the endothelium (lining of the blood vessels) thus dilating the arteries. It also prevents or reverses arterial plaque, keeping the artery walls flexible.
• NO increases blood flow when partially blocked arteries to the heart cause angina pain (which is how nitroglycerine pills work).
• NO increases blood flow when partially blocked arteries to the leg muscles cause muscle pain called intermittent claudication.
• The increased circulation dramatically reduces nerve and joint inflammation, providing relief for arthritis sufferers and improves healing of wounds and diabetic foot ulcers.
• NO lowers cholesterol – a clinical trial found that increasing NO lowered triglycerides by 27% in 30 days, from an average 232 down to 168 (mg/dL).
• Insulin requires NO to function properly; low levels of NO result in insulin resistance which, as I’ve written on extensively in past articles, can lead to obesity, high blood pressure, hyperlipidemia and Type 2 Diabetes.
• Low NO levels are associated with depression; treatment with antidepressants increases NO.
• NO is essential for both short-term and long-term memory.
• NO is also essential for penile erection; a deficiency of NO is a common cause of erectile dysfunction in older men.
• As we age, NO production in our bodies decreases; most people over 40 don’t produce enough. A simple saliva test can tell you where your level is.

Until recently taking arginine has been the best way to increase NO, but a much more effective supplement called Neo40 is now available in Canada. For more information on NO and Neo-40 see www.neo40.ca and a book called “The Nitric Oxide (NO) Solution” by Nathan S Bryan and Janet Zand, 2010.

With all these functions of nitric oxide, and most of us over 40 having insufficient levels, Neo40 has tremendous potential for improving our health in many different ways. I’m excited to learn what it will do for me. How about you?

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.