489 Liposomal Vitamin C [17 Sept 2018]

A problem with vitamin C is its low bioavailability. With oral supplements some of the vitamin C is broken down by stomach acids before it even reaches the small intestine. An active transporter is required to move vitamin C across the intestinal wall into the blood stream. This transporter is dose-dependent - at low doses of up to 180mg about 70-90% of vitamin C is absorbed into the bloodstream; at higher doses above 1000mg (1g) it is less than 50%. At doses between 5g and 10g daily, abdominal cramping and diarrhea may occur creating an upper limit to daily oral dosage of C. Even then, only a percentage of vitamin C is absorbed from the blood stream into the cells. This absorption into the cells is inhibited by high blood glucose, so is even more a problem for diabetics.

For certain therapeutic purposes much higher doses of vitamin C are required. One way around this is intravenous vitamin C (IVC). This is expensive and requires supervision by a trained health professional, so is used only for serious conditions like cancer [see #375], sepsis [#436], polio [#23], and other serious viral infections.

Now there is another form of vitamin C that allows high doses, is relatively inexpensive, and can be administered at home. It’s called liposomal vitamin C.

With liposomal C, the vitamin is encapsulated inside a tiny phospholipid ball which provides several advantages: 1) it protects the vitamin C from breakdown in the stomach; 2) it increases the absorption from the intestine into the blood stream; 3) it increases the absorption into the cells; and 4) it does so very quickly. Nearly all of the liposomal C ingested makes its way quickly into the cells where it is needed. In this regard liposomal C is superior to IVC which increases C in blood plasma but then relies on transporters to get it into the cells.

The phospholipid coating itself is used by the body to repair or build new cell membranes. It is because the coating is similar to cell membranes that it passes quickly and easily through the intestinal wall and then again through the cell membranes into the cells without the need for active transporters.

The big advantage of liposomal vitamin C is that it allows you to take, and absorb, a high dose of C when you need it, without experiencing intestinal discomfort. It’s perfect for fighting a cold or the flu, if you’re a smoker or subject to second-hand smoke, if you are diabetic, or for those days when you're under a lot of stress.

I have just found a Canadian supplier so will soon have it on the shelf. It comes in packets of 1000mg which you add to water and drink. I’ll be the first to try it and let you know what it does for me.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

488 Exogenous Ketones [10 Sept 2018]

A few weeks ago I wrote about the recent popularity of ketogenic diets [#482 30 July 2018]. These are very low carb diets with either low dietary fat for weight loss or higher dietary fat for other purposes. With both types of ketogenic diets, the main fuel burned for energy is fat – either your own stored fat or fat you eat. The metabolic state of burning fat for fuel is known as ketosis because the fat is first converted to ketones which are then converted to ATP energy in the cells’ mitochondria.

More recent is the promotion of ketone supplements – called exogenous ketones as opposed to endogenous ketones produced within the body. These supplements are purported to have similar benefits to ketogenic diets, but without the dieting. The theory sounds attractive but I’m not buying it. I believe it is the diet, with the reduction of carbs leading to a reduction in blood insulin levels, which provides most of the benefits. The ketones are just a byproduct of the process.

There may however be some benefits from ketone supplements. In a post on the blog The Diabetes Coach, titled “Are Exogenous Ketones Beneficial for Blood Sugar?” Dr Brian Mowll suggests that ketones enhance insulin sensitivity. He cites a small study from Oxford which showed lower glucose spikes with an oral glucose tolerance test for the group who had consumed a ketone drink.

But another ketogenic diet study, with obese diabetics, that Mowll cites as support that ketones increase insulin sensitivity did not include a ketone supplement. There is no evidence that it was the ketones, not the ketogenic diet itself, which provided the benefits.

In any case, if weight loss is the goal, adding extra fat or taking ketone supplements will only reduce the amount of body fat burned. And that, after all, is the whole idea.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

487 Fitbit Data Study [3 Sept 2018]

Do you wear a Fitbit? One of those wrist bands that records your heart rate, activity and sleep? Millions of people do and Fitbit recently looked at 150 billion hours of data to see what it could tell us about our health. Since this only includes people who own a Fitbit, the data may not apply to everyone. And relax, the data is anonymous – the researchers know your location, gender, age, height, weight, activity level, sleep habits, and continuous pulse rate, but not your name.

From previous studies we know that resting heart rate (RHR, measured in beats per minute) is a significant measure of our overall health. Most people fall in the range of 60 to 100, with athletes 40 to 50. The Copenhagen Heart Study found that, compared to someone with an RHR of under 50, your risk of death from heart disease is twice as high if your RHR is 80 and three times as high if over 90. A study from China found that for every RHR increase of 10, the risk of developing diabetes increased 23%.

This is what the Fitbit study learned:
• As we age, our RHR increases to a peak about age 40-50, then continuously declines from there for unknown reasons.
• On average, women have a higher rate than men, by 5 beats at age 20, and 2 to 3 beats from age 35-80. This is because women have smaller hearts.
• The optimal Body Mass Index (BMI) for heart function seems to be 20 to 25. RHR increases with increasing BMI above or below that range.
• RHR decreases with exercise (no surprise). After 300 minutes a week (an hour daily for 5 days), however, the decrease is small.
• The reduction in RHR from exercise declines with age. Increasing activity by 3 hours a week will lower your RHR by about 7 beats in your 30s, 40s and 50s, but only by 4 beats in your 60s and 3 beats in your 70s. Still, this shows that getting more active is beneficial at any age.
• Sleep lowers your RHR but only to an average of 7 hours after which it rises again. So get your sleep, then get out of bed and get moving!
• There are other unknown factors affecting heart rate. For the same activity level, the average RHR in the USA is 3 beats higher than Italy, and Canada is 2.5 beats higher than Ireland. Perhaps it’s our junk food diet?

See "Fitbit's 150 billion hours of heart data reveal secrets about health" by David Pogue, yahoo Finance, 27 Aug 2018 for more details and graphs that reveal these trends.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner. Find this article on my website for links to sources and further reading.

486 Keeping It Off [27 August 2018]

Most dieters will agree that it’s easier to lose weight than to keep it off. Once we have achieved our goal weight we tend to revert to our old eating habits and the pounds start creeping back on. Remember, weight gain is normal and natural. Here are some strategies for maintaining our desired weight:
• Have a Plan – just like in the weight-losing phase, having a plan directs and motivates us to achieve our new objective.
• Accountability – keep in close contact with your coach through the first year post diet – weekly the first few months, then monthly for the rest of the year. Then check in a few times a year as needed.
• Journaling – several studies show that keeping a food journal increases our rate of successfully keeping the weight off. It increases our awareness of what we are eating; helps identify problem habits, and creates accountability (even if just to our self).
• Exercise daily – with a ketogenic diet, exercise is not necessary for losing fat weight, but it is very important in maintaining our weight. Resistance training exercises (lifting weights) increases muscle mass, further improving our body fat ratio.
• Choose Healthy Foods – strictly limit simple carbs; choose healthy fats; eat sufficient high quality protein (more on this another week)
• Proper Food Combinations – separate carb-rich and fat-rich meals
• Some Quick Tips
o Start the day with a hearty breakfast.
o Don’t shop on an empty stomach.
o Eat mindfully, especially snacking.
o Control food portions; resist second helpings.
o Hot meals are more filling than cold.
o Stay hydrated – drink at least 2 liters of water daily.
o Use alcohol with moderation
o Get enough sleep.
• Reward yourself – each month you meet your maintenance target, treat yourself with something non-fattening like a night out, massage or pedicure.
• Reboot your metabolism for a few weeks every year with the ketogenic diet to return to your desired weight.

Further reading:
"How to keep weight off forever" WebMD
"Ten Habits of People Who Lose Weight and Keep it Off" theconversation.com

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

485 Inherited Stress [20 Aug 2018]

There’s an old joke that insanity is hereditary – you get it from your children. What parent hasn’t at some point exclaimed “You kids are driving me crazy!” Less funny perhaps, but more fascinating is what scientists have learned recently about heredity and health. Dr. Emeran Mayer, devotes Chapter 5 of his 2016 book “The Mind-Gut Connection” to the effects of early life experiences on gut-brain communication.

Stressful family events during childhood, in the womb, or even prior to conception, can affect our health in surprising ways: lowering our tolerance to stress; increasing our risk for anxiety, depression, digestive disorders like IBS (irritable bowel syndrome), diarrhea or constipation; and causing unhealthy changes to our gut microbiome. Babies born to highly stressed mothers have lower birth weights and are more prone to infections. Brain scans of adults with significant adverse childhood experiences (death of a parent, divorce, abuse, etc.) show abnormalities in brain structure and function.

In animal studies baby rats who were neglected or whose mothers were stressed, developed health problems similar to anxiety, depression, and addiction, while the nurtured pups developed into relaxed normal adult rats. The nurtured pups grew up to be nurturing mothers while the neglected pups became neglecting mothers. This wasn’t just learned behavior – it was hard wired into their hormonal and neurological systems during infancy.

These changes can be passed on to the second and third generation by a process called epigenetics [see #269 May 2014]. Epigenetics is the study of markers that turn genes on or off while leaving them intact. If this happens to reproductive cells, these markers can be passed on to your children.

How can we apply this information to improve our children’s health? First, minimize maternal stress during pregnancy and early childhood (easier said than done – refer back to the first line!). This is where Dad’s support is critical. Secondly, provide a loving secure home for the kids from birth through their teens. Thirdly, ensure the children’s microbiomes are as healthy as possible (more on that in a future article). Finally, don’t blame yourself for your kids’ health problems – blame your parents! [smile!]

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.

484 Our Complex Gut [13 August 2018]

In grade school health we were taught that our digestive system was a fairly simple “food processing machine” comprised of a handful of organs. Food entered at one end, a variety of digestive juices were added along the way, nutrients were extracted, and the leftover waste expelled out the other end. Scientists are just now discovering how complex our digestive system really is.

Dr. Emeran Mayer in his 2016 book “The Mind-Gut Connection – how the hidden conversation in our bodies impacts our mood, our choices, and our overall health” shares what cutting-edge science has learned about the connections between our gut, our brain, and our microbiome. This adds to previous articles I wrote about the brain-gut axis: #320 in May 2015 and #422 in May 2017.

First, the gut has its own nervous system, sometimes called the “second brain”. The enteric nervous system (ENS), as it is properly named, rivals the spinal cord for number of nerve cells – some 50-100 million. The ENS makes the gut the largest sensory organ of the body – covering an area the size of a basketball court.

The gut contains more immune cells than in all the rest of the body. There is a good reason for this – the gut is exposed to more pathogenic microbes than any other system. It can identify and destroy a pathogenic species out of the approximately 1,000 species that may exist in our gut.

The gut contains more endocrine cells than in all the other endocrine glands put together – adrenals, thyroid, pituitary, etc. The gut produces and stores 95% of the body’s serotonin, the neurotransmitter that controls our mood, sleep, appetite, and pain sensitivity.

Then there is the microbiome. Technological advances in DNA testing over the past few decades has allowed us to identify the thousands of microbial species that typically inhabit our body. There are about as many microbial cells in and on our body as there are human cells (if you include the red blood cells). By weight our microbiome is more massive than our brain. And since there are over 1,000 species, their collective genes outnumber our own a hundred fold.

These gut systems communicate with the brain in different ways. The large vagus nerve directly connects the gut and the brain. The hormones and neurotransmitters produced by the cells in the gut wall, and the metabolites produced by the microbes, can travel by the bloodstream to the brain. Mayer calls this complex three-way communication system the “Gut-Microbiome-Brain Axis”.

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner. Find this article on my website for links to sources and further reading.

483 The Placebo Effect [6 Aug 2018]

In the first few chapters of her 2016 book “Cure – a Journey into the Science of Mind over Body”, Jo Marchant explores the placebo effect.

The placebo effect is stronger and more widespread than I had realized. An enlightening example was the 1996 discovery that the enzyme secretin dramatically improved some autistic children, which when tested (in 1999) was found to work no better than a placebo. It did work, but so did the placebo (a saline injection); both groups improved significantly.

Another example is the surgical technique vertebroplasty (essentially gluing cracked vertebrae) which in a controlled study was found to be no better than placebo (a sham surgery). Again both groups improved significantly in mobility and pain relief.

So the placebo effect is more than just random improvement – there is a measurable beneficial effect due to patients’ expectations. And studies are discovering physiological changes in the body in response to these expectations which likely account for most of the favorable results. Some examples: a Parkinson’s drug placebo increases dopamine production; and a placebo pain killer increases production of endorphins (our body’s natural painkillers). Patients aren’t imagining the improvements – they are real.

The benefits of placebos are, however, limited to effects the body can control. A placebo can reduce pain, anxiety and depression, improve sleep, and lower blood pressure, but can’t replace insulin, shrink a tumor or lower cholesterol.

The author believes that any benefits from many alternative medicines and treatments like homeopathics and Reiki are due to the placebo effect. But she also reports that half of 53 surgical procedures studied in 2014, and most antidepressant drugs like Prozac, work little better than placebo. Valium for example only works if the patients know they are taking it. These drugs are still being marketed, and vertebroplasty surgery is still being performed. The author even proposes prescribing placebos, with the patients’ knowledge, in certain cases.

I’d love to see more controlled studies of natural products to learn how well they really work compared to conventional treatments. But I would still sell products that proved no better than placebo – if the customer asked for them and it was safe to do so. Why not harness the power of the mind to improve our health?

For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.