Professor John White and associates at McGill have recently discovered a possible mechanism for vitamin D’s protective effect on cancer. Vitamin D suppresses cMYC, an RNA protein that causes cell proliferation and is known to be more active in cancer cells (note: estrogens increase cMYC activity). It also enhances the expression of MXD1 a protein that is antagonistic to cMYC.
White was quoted in a report on the study by Nathan Gray in nutraingredients.com:
“Our results show that vitamin D puts the brakes on cMYC function, suggesting that it may slow the progression of cells from premalignant to malignant states and keep their proliferation in check… We hope that our research will encourage people to maintain adequate vitamin D supplementation and will stimulate the development of large, well-controlled cancer chemoprevention trials to test the effects of adequate supplementation.”
So what is adequate supplementation? Some vitamin D researchers consider the optimal range to be 50 – 65 ng/ml with the most protection at the higher end of the range. Cancer treatment would fall in the 65 – 90 range. Levels over 100 are now considered high. To achieve the optimal range, the current recommendation for supplementation is 35 IU per pound of body weight. At 200 lbs I would need 7,000 IU per day. This value would vary with season, sun exposure and skin color.
For more information on this or other natural health topics, stop in and talk to Stan; for medical advice consult your licensed health practitioner.